Molecular structure of Methysticin, CAS Number: 495-85-2
Methysticin (CAS 495-85-2)
Alternate Names:
Kavatin; Kavahin
Application:
Methysticin is an anxiolytic and neuroprotective compound isolated from kava kava
CAS Number:
495-85-2
Purity:
≥98%
Molecular Weight:
274.27
Molecular Formula:
C15H14O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methysticin is one of the main components in kava kava extract. It has anxiolytic effects and neuroprotective properties.
Methysticin (CAS 495-85-2) References
- Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm. | Smith, KK., et al. 2001. Psychopharmacology (Berl). 155: 86-90. PMID: 11374340
- Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. | Backhauss, C. and Krieglstein, J. 1992. Eur J Pharmacol. 215: 265-9. PMID: 1396990
- Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. | Shaik, AA., et al. 2009. Bioorg Med Chem Lett. 19: 5732-6. PMID: 19716299
- Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro. | Tang, J., et al. 2011. Phytother Res. 25: 417-23. PMID: 20734326
- Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. | Li, Y., et al. 2011. Toxicol Sci. 124: 388-99. PMID: 21908763
- Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. | Fragoulis, A., et al. 2017. Redox Biol. 12: 843-853. PMID: 28448946
- Rapid detection and structural characterization of methysticin metabolites generated from rat and human liver microsomes and hepatocytes using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. | Tuerxuntayi, A., et al. 2021. Rapid Commun Mass Spectrom. 35: e9208. PMID: 34606659
- Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9. | Zhang, Q., et al. 2022. Chem Res Toxicol. 35: 1117-1124. PMID: 35583123
- Pharmacological effects of methysticin and L-sulforaphane through the Nrf2/ARE signaling pathway in MLO-Y4 osteocytes: in vitro study. | Dittmar, MC., et al. 2024. Ann Anat. 254: 152260. PMID: 38521364
- Effects of methysticin on three different models of seizure like events studied in rat hippocampal and entorhinal cortex slices. | Schmitz, D., et al. 1995. Naunyn Schmiedebergs Arch Pharmacol. 351: 348-55. PMID: 7630425
Inhibitor of:
CYP2A22.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methysticin, 5 mg | sc-205750 | 5 mg | $165.00 | |||
Methysticin, 10 mg | sc-205750A | 10 mg | $225.00 |