Date published: 2025-10-19

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Methylsuccinic acid (CAS 498-21-5)

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Alternate Names:
Pyrotartaric Acid
CAS Number:
498-21-5
Purity:
≥99%
Molecular Weight:
132.11
Molecular Formula:
C5H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methylsuccinic acid (MSA) is an organic acid, specifically a derivative of succinic acid. It presents itself as a white crystalline solid at room temperature and exhibits solubility in both water and alcohol. Methylsuccinic acid plays a role as an intermediate in the creation of a variety of compounds, such as dyes and fragrances. Moreover, it is utilized in the production of food additives, acting as a preservative and flavoring agent. Methylsuccinic acid has been a point of focus in research related to potential applications in fields such as biochemistry and physiology. It has been explored for its inhibitory effects on enzymes involved in metabolic pathways. Specifically, it has been found to inhibit the enzyme succinate dehydrogenase, a key player in the citric acid cycle, and the enzyme fumarase, which participates in the metabolism of fumaric acid. Methylsuccinic acid has also been inspected for its potential role in the regulation of cell growth and development.


Methylsuccinic acid (CAS 498-21-5) References

  1. D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach.  |  Williams, RE., et al. 2005. Toxicology. 207: 179-90. PMID: 15596249
  2. Phase changes during hygroscopic cycles of mixed organic/inorganic model systems of tropospheric aerosols.  |  Marcolli, C. and Krieger, UK. 2006. J Phys Chem A. 110: 1881-93. PMID: 16451021
  3. Fluorescence determination of N-acetylaspartic acid in the rat cerebrum homogenate using high-performance liquid chromatography with pre-column fluorescence derivatization.  |  Fukushima, T., et al. 2008. Biomed Chromatogr. 22: 100-5. PMID: 17703473
  4. Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia.  |  Loots, DT. 2009. J Inherit Metab Dis. 32: 403-11. PMID: 19343532
  5. Multiple sources of metabolic disturbance in ETHE1-related ethylmalonic encephalopathy.  |  Barth, M., et al. 2010. J Inherit Metab Dis. 33 Suppl 3: S443-53. PMID: 20978941
  6. Thioesterases for ethylmalonyl-CoA pathway derived dicarboxylic acid production in Methylobacterium extorquens AM1.  |  Sonntag, F., et al. 2014. Appl Microbiol Biotechnol. 98: 4533-44. PMID: 24419796
  7. Effects of Constituent Compounds of Smilax china on Nicotine-Induced Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells.  |  Lincha, VR., et al. 2016. Biol Pharm Bull. 39: 984-92. PMID: 27251500
  8. Urinary Time- or Dose-Dependent Metabolic Biomarkers of Aristolochic Acid-Induced Nephrotoxicity in Rats.  |  Hu, X., et al. 2017. Toxicol Sci. 156: 123-132. PMID: 28115647
  9. Highly selective one-step dehydration, decarboxylation and hydrogenation of citric acid to methylsuccinic acid.  |  Verduyckt, J. and De Vos, DE. 2017. Chem Sci. 8: 2616-2620. PMID: 28553496
  10. Protoenzymes: the case of hyperbranched polyesters.  |  Mamajanov, I. and Cody, GD. 2017. Philos Trans A Math Phys Eng Sci. 375: PMID: 29133454
  11. Pyruvate Aldol Condensation Product: A Metabolite That Escaped Synthetic Preparation for Over a Century.  |  Rios, AC., et al. 2020. ACS Omega. 5: 15063-15068. PMID: 32637778
  12. Genomic Analysis of Historical Cases with Positive Newborn Screens for Short-Chain Acyl-CoA Dehydrogenase Deficiency Shows That a Validated Second-Tier Biochemical Test Can Replace Future Sequencing.  |  Adhikari, AN., et al. 2020. Int J Neonatal Screen. 6: PMID: 32802992
  13. Supplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats.  |  Huang, J., et al. 2021. Appl Microbiol Biotechnol. 105: 287-299. PMID: 33128611
  14. Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells.  |  Kuang, B., et al. 2021. Metab Eng Commun. 13: e00182. PMID: 34522610
  15. Multiplexed LC-MS/MS analysis of methylsuccinic acid, ethylmalonic acid, and glutaric acid in plasma and urine.  |  Peng, KW., et al. 2022. Anal Biochem. 645: 114604. PMID: 35217005

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methylsuccinic acid, 25 g

sc-250400
25 g
$94.00