Date published: 2026-4-5

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Methylphosphonic acid (CAS 993-13-5)

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CAS Number:
993-13-5
Purity:
98%
Molecular Weight:
96.02
Molecular Formula:
CH5O3P
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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Methylphosphonic acid, a one-carbon compound, is a type of phosphonic acid where a hydrogen atom connected to phosphorus is replaced by a methyl group. As a member of phosphonic acids, it originates from phosphonic acid and serves as the conjugate acid of methylphosphonate(1-). To synthesize Methylphosphonic acid, one can employ a catalyst during the reaction of trimethyl phosphite with hydrogen peroxide.


Methylphosphonic acid (CAS 993-13-5) References

  1. Quantification of sarin and cyclosarin metabolites isopropyl methylphosphonic acid and cyclohexyl methylphosphonic acid in minipig plasma using isotope-dilution and liquid chromatography- time-of-flight mass spectrometry.  |  Evans, RA., et al. 2008. J Anal Toxicol. 32: 78-85. PMID: 18269798
  2. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.  |  Gupte, R., et al. 2011. ChemMedChem. 6: 922-35. PMID: 21465666
  3. Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean.  |  Metcalf, WW., et al. 2012. Science. 337: 1104-7. PMID: 22936780
  4. Rapid IC-MS/MS determination of methylphosphonic acid in urine of rats exposed to organophosphorus nerve agents.  |  Baygildiev, T., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1058: 32-39. PMID: 28531843
  5. Efficient derivatization of methylphosphonic and aminoethylsulfonic acids related to nerve agents simultaneously in soils using trimethyloxonium tetrafluoroborate for their enhanced, qualitative detection and identification by EI-GC-MS and GC-FPD.  |  Valdez, CA., et al. 2018. Forensic Sci Int. 288: 159-168. PMID: 29753153
  6. Methylphosphonic Acid Biosynthesis and Catabolism in Pelagic Archaea and Bacteria.  |  Ulrich, EC., et al. 2018. Methods Enzymol. 605: 351-426. PMID: 29909833
  7. An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.  |  Gama, SR., et al. 2019. ACS Chem Biol. 14: 735-741. PMID: 30810303
  8. A Brief Overview of HPLC-MS Analysis of Alkyl Methylphosphonic Acid Degradation Products of Nerve Agents.  |  B'Hymer, C. 2019. J Chromatogr Sci. 57: 606-617. PMID: 30994880
  9. Methodological aspects of methylphosphonic acid analysis: Determination in river and coastal water samples.  |  Lohrer, C., et al. 2020. Talanta. 211: 120724. PMID: 32070570
  10. Hydrolysis of methylphosphonic anhydride solid to methylphosphonic acid probed by Raman and infrared reflectance spectroscopies.  |  Myers, TL., et al. 2021. Anal Methods. 13: 3863-3873. PMID: 34397072
  11. Mechanism of methylphosphonic acid photo-degradation based on phosphate oxygen isotopes and density functional theory.  |  Xia, C., et al. 2019. RSC Adv. 9: 31325-31332. PMID: 35527942
  12. Utilization of phosphonic acid compounds by marine bacteria of the genera Phaeobacter, Ruegeria, and Thalassospira (α-Proteobacteria).  |  Urata, S., et al. 2022. FEMS Microbiol Lett. 369: PMID: 35906193
  13. Analysis of methylphosphonic acid, ethyl methylphosphonic acid and isopropyl methylphosphonic acid at low microgram per liter levels in groundwater.  |  Sega, GA., et al. 1997. J Chromatogr A. 790: 143-52. PMID: 9435117

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methylphosphonic acid, 1 g

sc-250399
1 g
$28.00
US: Only available in the US

Methylphosphonic acid, 5 g

sc-250399A
5 g
$87.00
US: Only available in the US

Methylphosphonic acid, 25 g

sc-250399B
25 g
$223.00
US: Only available in the US

Methylphosphonic acid, 100 g

sc-250399C
100 g
$884.00
US: Only available in the US

Methylphosphonic acid, 1 kg

sc-250399D
1 kg
$5826.00
US: Only available in the US

Methylphosphonic acid, 2.5 kg

sc-250399E
2.5 kg
$13525.00
US: Only available in the US