Molecular structure of Methylmalonic acid, CAS Number: 516-05-2
Methylmalonic acid (CAS 516-05-2)
Alternate Names:
2-Methylpropanedioic acid
CAS Number:
516-05-2
Molecular Weight:
118.09
Molecular Formula:
C4H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Methylmalonic acid is primarily recognized in biochemical research circles for its role as a significant intermediate in the metabolism of fats and proteins. Studies frequently focus on its accumulation in various organisms as a marker for understanding metabolic disorders at the cellular level. Biochemists leverage methylmalonic acid as a tool for probing the intricacies of metabolic pathways, such as the conversion of propionyl-CoA to succinyl-CoA, an essential step in the citric acid cycle. In the field of genetics, it serves as a key molecule in research aimed at dissecting the genetic basis of certain metabolic deficiencies, which are linked to the improper processing of this molecule.
Methylmalonic acid (CAS 516-05-2) References
- Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions. | Fighera, MR., et al. 1999. Neuroreport. 10: 2039-43. PMID: 10424671
- Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | Klee, GG. 2000. Clin Chem. 46: 1277-83. PMID: 10926922
- Methylmalonic acid--an endogenous toxin? | Kölker, S. and Okun, JG. 2005. Cell Mol Life Sci. 62: 621-4. PMID: 15770414
- Methylmalonic acid administration induces DNA damage in rat brain and kidney. | Andrade, VM., et al. 2014. Mol Cell Biochem. 391: 137-45. PMID: 24532006
- Age-induced accumulation of methylmalonic acid promotes tumour progression. | Gomes, AP., et al. 2020. Nature. 585: 283-287. PMID: 32814897
- Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats. | Bjune, MS., et al. 2021. Biochim Biophys Acta Mol Cell Biol Lipids. 1866: 158887. PMID: 33454435
- Methylmalonic Acid Compromises Respiration and Reduces the Expression of Differentiation Markers of SH-SY5Y Human Neuroblastoma Cells. | da Costa, RT., et al. 2021. ACS Chem Neurosci. 12: 2608-2618. PMID: 34191487
- Altered propionate metabolism contributes to tumour progression and aggressiveness. | Gomes, AP., et al. 2022. Nat Metab. 4: 435-443. PMID: 35361954
- Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness. | Kay, EJ. and Zanivan, S. 2022. Nat Metab. 4: 412-413. PMID: 35361957
- Ni Nanoparticles Embedded Ti3C2Tx-MXene Nanoarchitectures for Electrochemical Sensing of Methylmalonic Acid. | Kumar, J., et al. 2022. Biosensors (Basel). 12: PMID: 35448291
- LC-MS/MS Method for High-Throughput Analysis of Methylmalonic Acid in Serum, Plasma, and Urine: Method for Analyzing Isomers Without Chromatographic Separation. | Kushnir, MM., et al. 2022. Methods Mol Biol. 2546: 295-309. PMID: 36127599
- Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. | Li, Z., et al. 2022. Nat Commun. 13: 6239. PMID: 36266345
- Methylmalonic acid inhibits respiration in rat liver mitochondria. | Toyoshima, S., et al. 1995. J Nutr. 125: 2846-50. PMID: 7472665
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methylmalonic acid, 5 g | sc-250397 | 5 g | $50.00 |