Molecular structure of Methyllycaconitine Perchlorate, Delphinium sp.
Methyllycaconitine Perchlorate, Delphinium sp.
Application:
Methyllycaconitine Perchlorate, Delphinium sp. is an α-bungarotoxin neuronal nicotinic receptor antagonist
Molecular Weight:
783.3
Molecular Formula:
C37H50N2O10•HClO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Methyllycaconitine Perchlorate, Delphinium sp. is a α-Bungarotoxin neuronal nicotinic receptor (nAChR) antagonist. It has high affinity (nM range) for a subtype of the neuronal acetylcholine receptor (nAchR) in the brain which probably incorporates the α7-subunit. It exhibits micromolar affinity for muscle acetylcholine receptor and for α-bungarotoxin-insensitive neuronal nAChR. Reconstitution experiments in Xenopus oocytes have shown the effects of methyllycaconitine on nAChR to be highly specific for the α7-subtype (IC50 = 0.1 nM), but not for the α3β4-subtype (IC50 = 1 μM). This can be used to distinguish between neuronal and muscular nicotinic receptors.
Methyllycaconitine Perchlorate, Delphinium sp. References
- Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist. | Alkondon, M., et al. 1992. Mol Pharmacol. 41: 802-8. PMID: 1569927
- Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding sites. | Ward, JM., et al. 1990. FEBS Lett. 270: 45-8. PMID: 2226787
- Presence of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat olfactory bulb neurons. | Alkondon, M. and Albuquerque, EX. 1994. Neurosci Lett. 176: 152-6. PMID: 7830936
- Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. | Pereira, EF., et al. 1993. J Pharmacol Exp Ther. 265: 1474-91. PMID: 8510023
- Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. | López, MG., et al. 1998. Proc Natl Acad Sci U S A. 95: 14184-9. PMID: 9826675
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methyllycaconitine Perchlorate, Delphinium sp., 5 mg | sc-221938 | 5 mg | $126.00 |