Date published: 2026-4-24

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Methylisothiazolinone (CAS 2682-20-4)

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Alternate Names:
2-Methyl-4-isothiazolin-3-one
CAS Number:
2682-20-4
Molecular Weight:
115.15
Molecular Formula:
C4H5NOS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methylisothiazolinone is a biocide that functions as a preservative in various industrial and commercial products. It acts by disrupting the function of enzymes within microorganisms, leading to the inhibition of their growth and reproduction. Methylisothiazolinone exerts its mode of action by binding to specific proteins and interfering with their normal activity, ultimately causing cell death in susceptible organisms. Methylisothiazolinone is effective at very low concentrations, making it a potent antimicrobial agent in a wide range of applications. Its mechanism of action involves the disruption of cellular processes, leading to the elimination of microbial contaminants and the preservation of products. Methylisothiazolinone′s function as a preservative is attributed to its ability to target and disrupt the biological functions of microorganisms, thereby extending the shelf life and stability of various formulations.


Methylisothiazolinone (CAS 2682-20-4) References

  1. Methylisothiazolinone contact allergy: a review.  |  Lundov, MD., et al. 2011. Br J Dermatol. 165: 1178-82. PMID: 21777214
  2. The methylisothiazolinone epidemic: Is the fire out or is Rome still burning?  |  . 2014. Contact Dermatitis. 70: 67-8. PMID: 24450823
  3. Methylchloroisothiazolinone-methylisothiazolinone (Kathon CG).  |  Larsen, WG. 1989. J Am Acad Dermatol. 20: 703. PMID: 2523905
  4. Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries.  |  Schwensen, JF., et al. 2015. Contact Dermatitis. 72: 127-38. PMID: 25510184
  5. Contact allergy caused by methylisothiazolinone: the Belgian-French experience.  |  Aerts, O., et al. 2015. Eur J Dermatol. 25: 228-33. PMID: 26412037
  6. [Photo-aggravated eczema caused by methylisothiazolinone].  |  Schmutz, JL. 2018. Ann Dermatol Venereol. 145: 78-79. PMID: 29037429
  7. Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics.  |  Burnett, CL., et al. 2019. Int J Toxicol. 38: 70S-84S. PMID: 31170842
  8. Methylisothiazolinone in cosmetic products in Tunisia.  |  Belhareth, K., et al. 2020. Contact Dermatitis. 82: 128-129. PMID: 31591724
  9. Methylisothiazolinone and isothiazolinone allergy.  |  Reeder, M. and Atwater, AR. 2019. Cutis. 104: 94-96. PMID: 31603959
  10. Methylisothiazolinone: the new star of contact dermato-allergology.  |  Lachapelle, JM. 2020. J Eur Acad Dermatol Venereol. 34: 218. PMID: 31997498
  11. Methylisothiazolinone in children's nail polish.  |  Kullberg, SA., et al. 2020. Pediatr Dermatol. 37: 745-747. PMID: 32198778
  12. Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics.  |  Burnett, CL., et al. 2021. Int J Toxicol. 40: 5S-19S. PMID: 34259065
  13. Novel insights into contact dermatitis.  |  Johansen, JD., et al. 2022. J Allergy Clin Immunol. 149: 1162-1171. PMID: 35183605

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methylisothiazolinone, 1 g

sc-507193
1 g
$62.00

Methylisothiazolinone, 900 g

sc-507193A
900 g
$10404.00