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Methylhesperidin (CAS 11013-97-1)

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Alternate Names:
Methyl hesperidine
Application:
Methylhesperidin is a vasodilating agent
CAS Number:
11013-97-1
Molecular Weight:
624.59
Molecular Formula:
C29H36O15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methylhesperidin, a naturally occurring flavonoid abundant in citrus fruits, exhibits remarkable antioxidant properties and boasts a wide array of biological activities. Methylhesperidin finds extensive utility in scientific research. In vitro studies have investigated its antioxidant potential as well as its impacts on inflammation, cancer, and microbial growth. Methylhesperidin deploys multiple mechanisms of action. Notably, it has demonstrated the ability to inhibit key enzymes such as cyclooxygenase, lipoxygenase.


Methylhesperidin (CAS 11013-97-1) References

  1. Influence of some bioflavonoids on the transport of nitrendipine.  |  Rajnarayana, K., et al. 2008. Drug Metabol Drug Interact. 23: 299-310. PMID: 19326773
  2. Carcinogenicity study of methyl hesperidin in B6C3F1 mice.  |  Kurata, Y., et al. 1990. Food Chem Toxicol. 28: 613-8. PMID: 2272558
  3. Molecular spectroscopic on interaction between Methyl hesperidin and Buman serum albumin.  |  Li, J. and Wang, S. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 102: 200-4. PMID: 23220657
  4. Hydrolyzed Methylhesperidin Induces Antioxidant Enzyme Expression via the Nrf2-ARE Pathway in Normal Human Epidermal Keratinocytes.  |  Kuwano, T., et al. 2015. J Agric Food Chem. 63: 7937-44. PMID: 26313892
  5. Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice.  |  Donia, TIK., et al. 2018. Chem Biol Interact. 285: 76-84. PMID: 29481770
  6. Development of nobiletin-methyl hesperidin amorphous solid dispersion: Novel application of methyl hesperidin as an excipient for hot-melt extrusion.  |  Iwashita, M., et al. 2019. Int J Pharm. 558: 215-224. PMID: 30654059
  7. Untargeted Safety Pharmacology Screen of Blood-Activating and Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients as a Cause of Organ Damage in Experimental Models.  |  Liu, X., et al. 2019. Front Pharmacol. 10: 993. PMID: 31607901
  8. Effects of three drying methods on polyphenol composition and antioxidant activities of Litchi chinensis Sonn.  |  Tan, S., et al. 2020. Food Sci Biotechnol. 29: 351-358. PMID: 32257518
  9. [Vasodilating action of methylhesperidin].  |  Chen, QM. and Feng, GH. 1987. Zhongguo Yao Li Xue Bao. 8: 344-8. PMID: 3445778
  10. [Effect of methyl hesperidin on the prenatal development of rats].  |  Kawashima, K., et al. 1986. Eisei Shikenjo Hokoku. 64-8. PMID: 3567442
  11. Amentoflavone and methyl hesperidin, novel lead molecules targeting epitranscriptomic modulator in acute myeloid leukemia: in silico drug screening and molecular dynamics simulation approach.  |  Manna, S., et al. 2022. J Mol Model. 29: 9. PMID: 36522514
  12. The potentiation of the coronary dilating and the cardiac action of adenosine or adenine nucleotides by methylhesperidin.  |  Kikuchi, K., et al. 1966. Jpn J Pharmacol. 16: 224-5. PMID: 5297722
  13. The potentiating effect of methyl hesperidin on coronary vasodilation induced by adenosine or related compounds.  |  Tsunoo, M., et al. 1967. Arzneimittelforschung. 17: 979-80. PMID: 5632073
  14. Subchronic toxicity study of methyl hesperidin in mice.  |  Kawabe, M., et al. 1993. Toxicol Lett. 69: 37-44. PMID: 8356566

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methylhesperidin, 5 g

sc-204804
5 g
$68.00

Methylhesperidin, 25 g

sc-204804A
25 g
$181.00