Date published: 2026-4-5

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Methylboronic acid (CAS 13061-96-6)

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Alternate Names:
Methaneboronic acid
Application:
Methylboronic acid is a reagent for derivatizing many carbohydrates and biologically active compounds
CAS Number:
13061-96-6
Molecular Weight:
59.86
Molecular Formula:
CH5BO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methylboronic acid is a compound that functions as a Lewis acid in various chemical reactions. It acts as a catalyst in organic synthesis, particularly in the formation of carbon-carbon and carbon-oxygen bonds. The acid′s mode of action involves its ability to coordinate with electron-rich species, facilitating the activation of substrates and promoting the formation of new chemical bonds. In this capacity, it plays a role in the development of new methodologies and the production of complex organic molecules. Methylboronic acid′s reactivity with a range of functional groups makes it useful for the construction of diverse molecular architectures. Its ability to participate in cross-coupling reactions and other transformations contributes to the advancement of chemical research and the discovery of novel compounds.


Methylboronic acid (CAS 13061-96-6) References

  1. Gas chromatography/combustion/isotope-ratio-monitoring mass spectrometric analysis of methylboronic derivatives of monosaccharides: a new method for determining natural 13C abundances of carbohydrates.  |  van Dongen, BE., et al. 2001. Rapid Commun Mass Spectrom. 15: 496-500. PMID: 11268134
  2. Selective monomethylation of anilines by Cu(OAc)2-promoted cross-coupling with MeB(OH)2.  |  González, I., et al. 2009. Org Lett. 11: 1677-80. PMID: 19354317
  3. Preparation and synthetic application of partially protected brassinosteroids.  |  Khripach, VA., et al. 2010. Steroids. 75: 27-33. PMID: 19786042
  4. Determination of the stable carbon isotopic compositions of 2-methyltetrols in ambient aerosols from the Changbai Mountains.  |  Li, L., et al. 2010. Rapid Commun Mass Spectrom. 24: 1625-8. PMID: 20486258
  5. The spectroscopic (FTIR, FT-Raman, NMR and UV), first-order hyperpolarizability and HOMO-LUMO analysis of methylboronic acid.  |  Rani, U., et al. 2012. Spectrochim Acta A Mol Biomol Spectrosc. 92: 67-77. PMID: 22446752
  6. Aerobic Copper-Catalyzed O-Methylation with Methylboronic Acid.  |  Jacobson, CE., et al. 2015. J Org Chem. 80: 7305-10. PMID: 26111825
  7. New evidences on efficacy of boronic acid-based derivatization method to identify sugars in plant material by gas chromatography-mass spectrometry.  |  Faraco, M., et al. 2016. Talanta. 159: 40-46. PMID: 27474277
  8. Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions.  |  Gupta, S., et al. 2017. Org Biomol Chem. 15: 8493-8498. PMID: 28952646
  9. Methylboronic acid fertilization alleviates boron deficiency symptoms in Arabidopsis thaliana.  |  Duran, C., et al. 2018. Planta. 248: 221-229. PMID: 29700610
  10. Regioselective single pot C3-glycosylation of strophanthidol using methylboronic acid as a transient protecting group.  |  Tay, JH., et al. 2019. J Antibiot (Tokyo). 72: 437-448. PMID: 30948784
  11. Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids.  |  Hinkes, SPA. and Klein, CDP. 2019. Org Lett. 21: 3048-3052. PMID: 31012586
  12. Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid.  |  Roscales, S. and Csákÿ, AG. 2019. ACS Omega. 4: 13943-13953. PMID: 31497712
  13. Facile deprotection of F-BODIPYs using methylboronic acid.  |  Smith, CD. and Thompson, A. 2020. RSC Adv. 10: 24273-24279. PMID: 35516207

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methylboronic acid, 1 g

sc-253040
1 g
$41.00