Molecular structure of Methyl pyruvate, CAS Number: 600-22-6
Methyl pyruvate (CAS 600-22-6)
Alternate Names:
Pyruvic acid methyl ester; Methyl 2-oxopropionate; Methylglyoxylic acid methyl ester
Application:
Methyl pyruvate is a compound used in stimulus-secretion coupling
CAS Number:
600-22-6
Purity:
≥90%
Molecular Weight:
102.09
Molecular Formula:
C4H6O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Methyl pyruvate is a compound used in stimulus-secretion coupling. Studies indicate that Methyl pyruvate increases free calcium ion concentration in the cytosol of pancreatic cells. In addition, it is believed that Methyl pyruvate stimulates the production of ATP, which is supported by the fact that Methyl pyruvate depolarizes mitochondrial membrane potential, similar to glucose. Studies on Jurkat T-lymphocyte mitochondria show that Methyl pyruvate directly inhibits cation current across the membrane, which suggests that this compound is not a mitochondrial substrate. Furthermore, the inhibition of the K(ATP) channels mediates the induction of electrical activity in pancreatic beta cells.
Methyl pyruvate (CAS 600-22-6) References
- Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP. | Lembert, N., et al. 2001. Biochem J. 354: 345-50. PMID: 11171113
- Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats. | Valverde, I., et al. 2001. Int J Mol Med. 7: 621-3. PMID: 11351275
- Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate. | Düfer, M., et al. 2002. Biochem J. 368: 817-25. PMID: 12350226
- Keto-enol driven assembly of methyl pyruvate on Pt(111). | Lavoie, S., et al. 2007. J Am Chem Soc. 129: 11668-9. PMID: 17784756
- (E)-Methyl 2-[(4-nitro-phen-yl)-hydrazono]-propanoate. | Yu, HY., et al. 2007. Acta Crystallogr Sect E Struct Rep Online. 64: o344. PMID: 21200906
- Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis. | Tagashira, H., et al. 2014. Biochim Biophys Acta. 1840: 3320-34. PMID: 25175561
- Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy. | Monchusi, B. and Ntwasa, M. 2017. PLoS One. 12: e0182789. PMID: 28797070
- Correction: Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy. | ,. 2018. PLoS One. 13: e0194260. PMID: 29630624
- Electroanalysis of Infection with Methyl Pyruvate. | Bekhit, M. and Gorski, W. 2020. ACS Sens. 5: 535-540. PMID: 32036647
- The progress of type II persisters of Escherichia coli O157:H7 to a non-culturable state during prolonged exposure to antibiotic stress with revival being aided through acid-shock treatment and provision of methyl pyruvate. | Chen, H., et al. 2021. Can J Microbiol. 67: 518-528. PMID: 33125853
- In vitro and in vivo insulinotropic action of methyl pyruvate. | Leclercq-Meyer, V., et al. 1995. Horm Metab Res. 27: 477-81. PMID: 8770621
- Insulinotropic action of methyl pyruvate: secretory, cationic, and biosynthetic aspects. | Malaisse, WJ., et al. 1996. Arch Biochem Biophys. 335: 229-44. PMID: 8914920
- Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects. | Jijakli, H., et al. 1996. Arch Biochem Biophys. 335: 245-57. PMID: 8914921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methyl pyruvate, 25 g | sc-250384 | 25 g | $35.00 |