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Methyl paraben (CAS 99-76-3)

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Alternate Names:
Methyl 4- Hydroxybenzoate
Application:
Methyl paraben is an analytical reagent for sterol hormone studies
CAS Number:
99-76-3
Molecular Weight:
152.15
Molecular Formula:
C8H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl paraben, a compound within the paraben family of preservatives, is frequently used in the field of material science and conservation research. It is incorporated into studies focusing on the preservation of organic materials, where its efficacy in inhibiting microbial growth is of particular interest. In addition, methyl paraben is employed as a model compound for understanding the behavior of esters in various chemical environments. Its stability under different conditions, such as pH and temperature, is examined to inform the development of more effective preservation strategies. Furthermore, the compound is used in analytical chemistry research, where its properties are useful in the development of new chromatographic methods for detecting and quantifying similar substances within complex mixtures. Methyl paraben is also a subject in environmental science research, particularly in the study of the persistence and effects of preservatives in ecosystems.


Methyl paraben (CAS 99-76-3) References

  1. Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract.  |  Avula, B., et al. 2007. Pharmazie. 62: 593-6. PMID: 17867553
  2. Combined activation of methyl paraben by light irradiation and esterase metabolism toward oxidative DNA damage.  |  Okamoto, Y., et al. 2008. Chem Res Toxicol. 21: 1594-9. PMID: 18656963
  3. Crystal engineering of pharmaceutical Co-crystals: application of methyl paraben as molecular hook.  |  Khan, M., et al. 2010. J Am Chem Soc. 132: 5254-63. PMID: 20235531
  4. A fast and direct spectrophotometric method for the simultaneous determination of methyl paraben and hydroquinone in cosmetic products using successive projections algorithm.  |  Esteki, M., et al. 2016. Int J Cosmet Sci. 38: 25-34. PMID: 25976453
  5. Relationships between the resistance of yeasts to acetic, propanoic and benzoic acids and to methyl paraben and pH.  |  Warth, AD. 1989. Int J Food Microbiol. 8: 343-9. PMID: 2641686
  6. Phototoxicity and chronic toxicity of methyl paraben and 1,2-hexanediol in Daphnia magna.  |  Lee, J., et al. 2017. Ecotoxicology. 26: 81-89. PMID: 27866342
  7. A study on the in vitro percutaneous absorption of silver nanoparticles in combination with aluminum chloride, methyl paraben or di-n-butyl phthalate.  |  Domeradzka-Gajda, K., et al. 2017. Toxicol Lett. 272: 38-48. PMID: 28315385
  8. Developmental toxicity and induction of vitellogenin in embryo-larval stages of zebrafish (Danio rerio) exposed to methyl Paraben.  |  Dambal, VY., et al. 2017. Ecotoxicol Environ Saf. 141: 113-118. PMID: 28324817
  9. Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro models.  |  Kizhedath, A., et al. 2019. Toxicol In Vitro. 55: 108-115. PMID: 30572011
  10. A New Sensor for Methyl Paraben Using an Electrode Made of a Cellulose Nanocrystal-Reduced Graphene Oxide Nanocomposite.  |  Wan Khalid, WEF., et al. 2019. Sensors (Basel). 19: PMID: 31216625
  11. Electrochemical degradation of a methyl paraben and propylene glycol mixture: Interference effect of competitive oxidation and pH stability.  |  Dionisio, D., et al. 2022. Chemosphere. 287: 132229. PMID: 34547562
  12. The potential implications of estrogenic and antioxidant-dependent activities of high doses of methyl paraben on MCF7 breast cancer cells.  |  Elsehly, WM., et al. 2022. J Biochem Mol Toxicol. 36: e23012. PMID: 35174924
  13. Investigation of combined effects of propyl paraben and methyl paraben on the hypothalamic-pituitary-adrenal axis in male rats.  |  İnkaya, EN. and Barlas, N. 2022. Toxicol Ind Health. 38: 687-701. PMID: 36066884
  14. Effect of 2-hydroxypropyl-beta-cyclodextrin on percutaneous absorption of methyl paraben.  |  Tanaka, M., et al. 1995. J Pharm Pharmacol. 47: 897-900. PMID: 8708982

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl paraben, 100 g

sc-218815
100 g
$66.00

Methyl paraben, 250 g

sc-218815A
250 g
$82.00

Methyl paraben, 1 kg

sc-218815B
1 kg
$286.00

Methyl paraben, 5 kg

sc-218815C
5 kg
$796.00

Methyl paraben, 25 kg

sc-218815D
25 kg
$3106.00