Molecular structure of Methyl-d3-malonic acid, CAS Number: 42522-59-8
Methyl-d3-malonic acid (CAS 42522-59-8)
Alternate Names:
2-(Methyl-d3)propanedioic acid
CAS Number:
42522-59-8
Molecular Weight:
121.11
Molecular Formula:
C4H3D3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Methyl-d3-malonic acid, an isotope-labelled derivative of Methylmalonic Acid, is utilized as a clinical biomarker for assessing vitamin B12 status. It binds with coenzyme A to form methylmalonyl-CoA, a metabolic intermediate that undergoes a vitamin B12-dependent catalytic step to transform into succinic acid. In scientific research, Methyl-d3-malonic acid finds extensive use. It serves as a substrate in enzyme assays, enabling the study of enzymatic activity. Additionally, it aids in exploring the structure and function of proteins and other biological molecules, as well as investigating metabolic pathways and biochemical reactions.
Methyl-d3-malonic acid (CAS 42522-59-8) References
- Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid. | Vrethem, M., et al. 2003. Mult Scler. 9: 239-45. PMID: 12814169
- The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida. | van der Linden, IJ., et al. 2006. J Mol Med (Berl). 84: 1047-54. PMID: 17024475
- A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry. | Blom, HJ., et al. 2007. Clin Chem Lab Med. 45: 645-50. PMID: 17484628
- Application of metabolomic principles to disorders of nucleotide metabolism reveals new metabolic perturbations. | Snyder, FF., et al. 2008. Nucleosides Nucleotides Nucleic Acids. 27: 641-7. PMID: 18600520
- Association between serum cobalamin and methylmalonic acid concentrations in dogs. | Berghoff, N., et al. 2012. Vet J. 191: 306-11. PMID: 21478039
- Liquid chromatographic-mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria. | Sriboonvorakul, N., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 941: 116-22. PMID: 24200840
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methyl-d3-malonic acid, 250 mg | sc-235857 | 250 mg | $1168.00 |