Date published: 2026-2-1

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Methyl 4-hydroxycinnamate (CAS 19367-38-5)

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Alternate Names:
4-coumaric acid methyl ester; Methyl p-hydroxycinnamate; p-hydroxy methyl cinnamate;
Application:
Methyl 4-hydroxycinnamate is an antifungal agent
CAS Number:
19367-38-5
Purity:
≥98%
Molecular Weight:
178.18
Molecular Formula:
C10H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl 4-hydroxycinnamate, a member of the cinnamate esters family derived from cinnamic acid, plays a significant role in the plant metabolic pathways, particularly in the biosynthesis of critical plant compounds like flavonoids and lignin. This compound, prevalent in various plants, demonstrates notable antioxidant properties, which are useful in studying plant defense mechanisms against environmental stressors, including UV radiation. The interest in methyl 4-hydroxycinnamate extends to its potential in research focused on understanding natural plant protection strategies, which may help in developing bio-inspired protective applications. Its function in these biochemical pathways highlights the complex interactions within plant cells and their adaptation to external threats through naturally occurring compounds.


Methyl 4-hydroxycinnamate (CAS 19367-38-5) References

  1. Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells.  |  Kubo, I., et al. 2004. Bioorg Med Chem. 12: 5349-54. PMID: 15388162
  2. High-resolution spectroscopy of methyl 4-hydroxycinnamate and its hydrogen-bonded water complex.  |  de Groot, M., et al. 2008. J Phys Chem B. 112: 4427-34. PMID: 18338881
  3. Characterization of two distinct feruloyl esterases, AoFaeB and AoFaeC, from Aspergillus oryzae.  |  Koseki, T., et al. 2009. Appl Microbiol Biotechnol. 83: 689-96. PMID: 19242690
  4. Spectroscopy and dynamics of methyl-4-hydroxycinnamate: the influence of isotopic substitution and water complexation.  |  Smolarek, S., et al. 2011. Phys Chem Chem Phys. 13: 4393-9. PMID: 21246114
  5. Nonradiative decay dynamics of methyl-4-hydroxycinnamate and its hydrated complex revealed by picosecond pump-probe spectroscopy.  |  Shimada, D., et al. 2012. Phys Chem Chem Phys. 14: 8999-9005. PMID: 22684331
  6. Conformational heterogeneity of methyl 4-hydroxycinnamate: a gas-phase UV-IR spectroscopic study.  |  Tan, EM., et al. 2013. J Phys Chem B. 117: 4798-805. PMID: 23574393
  7. Excited state dynamics of Photoactive Yellow Protein chromophores elucidated by high-resolution spectroscopy and ab initio calculations.  |  Tan, EM., et al. 2013. Faraday Discuss. 163: 321-40; discussion 393-432. PMID: 24020209
  8. Molecular beam and ab initio studies of photoactive yellow protein chromophores: influence of the thioester functionality and single bond rotation.  |  Tan, EM., et al. 2014. J Phys Chem B. 118: 12395-403. PMID: 25289691
  9. Antibacterial Constituents of Hainan Morinda citrifolia (Noni) Leaves.  |  Zhang, WM., et al. 2016. J Food Sci. 81: M1192-6. PMID: 27074391
  10. Mechanistic Photochemistry of Methyl-4-hydroxycinnamate Chromophore and Its One-Water Complexes: Insights from MS-CASPT2 Study.  |  Xie, XY., et al. 2016. J Phys Chem A. 120: 6014-22. PMID: 27398611
  11. Suppression of IL-8 Release by Sweet Olive Ethanolic Extract and Compounds in WiDr Colon Adenocarcinoma Cells.  |  Ye, YL., et al. 2017. J Food Sci. 82: 1792-1798. PMID: 28671329
  12. Anaerobic biodegradation of pyrene by Klebsiella sp. LZ6 and its proposed metabolic pathway.  |  Li, X., et al. 2020. Environ Technol. 41: 2130-2139. PMID: 30522413
  13. Effect of Secondary Metabolites of Tomato (Solanum lycopersicum) on Chemotaxis of Ralstonia solanacearum, Pathogen of Bacterial Wilt Disease.  |  Hasegawa, T., et al. 2019. J Agric Food Chem. 67: 1807-1813. PMID: 30734556
  14. Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction.  |  Trachtenberg, A., et al. 2019. Front Pharmacol. 10: 507. PMID: 31143124
  15. Structure-Activity Relationship of Hydroxycinnamic Acid Derivatives for Cooperating with Carnosic Acid and Calcitriol in Acute Myeloid Leukemia Cells.  |  Trachtenberg, A., et al. 2021. Biomedicines. 9: PMID: 34829746

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl 4-hydroxycinnamate, 1 g

sc-263638
1 g
$103.00

Methyl 4-hydroxycinnamate, 5 g

sc-263638A
5 g
$146.00