Methyl 4-Azido-4,6-dideoxy-2-O-methyl-3-O-benzyl-α-D-glucopyranoside (CAS 861819-28-5)

Methyl 4-azido-4,6-dideoxy-2-O-methyl-3-O-benzyl-α-D-glucopyranoside is a synthetic compound widely employed in glycobiology research due to its utility as a versatile glycosylation reagent and probe for studying carbohydrate-protein interactions. This chemical serves as a valuable precursor in the synthesis of structurally diverse oligosaccharides and glycoconjugates through glycosylation reactions. Its azido functional group enables selective modification of glycosyl acceptors under mild conditions via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or Staudinger ligation, facilitating the assembly of complex glycan structures. Moreover, methyl 4-azido-4,6-dideoxy-2-O-methyl-3-O-benzyl-α-D-glucopyranoside is utilized in the preparation of glycan microarrays for high-throughput screening of carbohydrate-binding proteins, lectins, and pathogens. By immobilizing glycans on solid supports, researchers can investigate glycan-mediated molecular recognition events, explain glycan-binding specificities, and identify potential targets or diagnostic biomarkers. Additionally, this compound finds application in the development of glycosylation methodologies and glycosylation inhibitors. Its ability to modulate glycosylation pathways and influence cellular processes underscores its importance in deciphering the roles of carbohydrates in health and disease and advancing research in glycoscience.