Methyl 3,5-dichloropyridine-4-carboxylate (CAS 773874-72-9)

Methyl 3,5-dichloropyridine-4-carboxylate, a chemical compound renowned for its distinctive properties, has emerged as a vital tool in scientific research. This pyridine derivative bears chlorine atoms attached to the 3 and 5 positions of the pyridine ring, along with a methyl ester group affixed to the 4 position.The versatility of Methyl 3,5-dichloropyridine-4-carboxylate has rendered it indispensable in various scientific investigations, primarily due to its capacity to inhibit specific enzyme activities. It has exhibited the ability to hinder the activity of a protein known as CDK9, which governs the regulation of cell division. Methyl 3,5-dichloropyridine-4-carboxylate acts as a CDK9 inhibitor by binding to the ATP-binding site of the protein. Through this interaction, it prevents the protein from phosphorylating its target substrates, which are indispensable for cell division. The inhibition of CDK9 culminates in the accumulation of cells in the G1 phase of the cell cycle, eventually leading to cellular demise.