Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside (CAS 4099-85-8)

Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside, a ribofuranoside derivative, has emerged as a valuable tool in carbohydrate chemistry and nucleoside synthesis research. Its unique structure, featuring an isopropylidene group, renders it chemically versatile for various synthetic transformations. In research, this compound has been extensively utilized as a building block for the synthesis of nucleoside analogs and nucleotide mimics, owing to its ability to serve as a protected ribose moiety. Through selective deprotection strategies, researchers have employed Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside to access diverse nucleoside structures with modified sugar functionalities, enabling investigations into structure-activity relationships and biological interactions. Additionally, its role as a glycosylation precursor has been instrumental in the synthesis of oligosaccharides and glycoconjugates for studying carbohydrate-protein interactions and glycobiology. Furthermore, this compound has found applications in the synthesis of modified RNA and DNA analogs for exploring nucleic acid chemistry and nucleic acid-based technologies. Its versatility as a synthetic intermediate makes Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside a valuable asset in the arsenal of researchers aiming to manipulate carbohydrate and nucleoside structures for various scientific inquiries, from elucidating molecular recognition events to developing novel materials.