Date published: 2026-4-30

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Methyl 2-[(succinimidooxy)carbonyl]benzoate (CAS 438470-19-0)

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CAS Number:
438470-19-0
Molecular Weight:
277.23
Molecular Formula:
C13H11NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl 2-[(succinimidooxy)carbonyl]benzoate is involved in the modification of proteins and peptides. It functions as a reagent for the introduction of succinimide-activated esters, which can react with primary amines in proteins and peptides to form stable amide bonds. Methyl 2-[(Succinimidooxy)Carbonyl]Benzoate is used to facilitate the conjugation of proteins or peptides to other molecules, such as fluorophores, enzymes, or solid supports, for various experimental purposes. Its mechanism of action involves the activation of the carboxyl group, allowing for the formation of stable amide bonds with primary amines in proteins or peptides. This enables the attachment of different functional groups to proteins or peptides, expanding their utility in experimental applications.


Methyl 2-[(succinimidooxy)carbonyl]benzoate (CAS 438470-19-0) References

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  2. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.  |  Brueckner, B., et al. 2005. Cancer Res. 65: 6305-11. PMID: 16024632
  3. Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases.  |  Schirrmacher, E., et al. 2006. Bioconjug Chem. 17: 261-6. PMID: 16536454
  4. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold.  |  Ballet, S., et al. 2007. Bioorg Med Chem Lett. 17: 2492-8. PMID: 17314042
  5. High-performance liquid chromatographic separation of stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics.  |  Ilisz, I., et al. 2007. J Sep Sci. 30: 1881-7. PMID: 17638345
  6. Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.  |  Novoa, A., et al. 2012. J Med Chem. 55: 9549-61. PMID: 23102273
  7. Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.  |  Asgatay, S., et al. 2014. J Med Chem. 57: 421-34. PMID: 24328113
  8. Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design.  |  Van der Poorten, O., et al. 2016. J Med Chem. 59: 10865-10890. PMID: 27690430
  9. χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.  |  Van der Poorten, O., et al. 2017. ACS Med Chem Lett. 8: 1177-1182. PMID: 29152051
  10. Synthesis of the Aminovinylcysteine-Containing C-Terminal Macrocycle of the Linaridins.  |  Lutz, JA. and Taylor, CM. 2020. Org Lett. 22: 1874-1877. PMID: 32043888

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl 2-[(succinimidooxy)carbonyl]benzoate, 5 g

sc-235656
5 g
$89.00