Date published: 2026-4-4

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Methyl 12-hydroxystearate (CAS 141-23-1)

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Alternate Names:
12-Hydroxystearic acid methyl ester; Methyl 12-hydroxyoctadecanoate
CAS Number:
141-23-1
Molecular Weight:
314.50
Molecular Formula:
C19H38O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl 12-hydroxystearate, identified by CAS number 141-23-1, is a methyl ester derivative of hydroxystearic acid. This compound is characterized by a hydroxyl group at the 12th carbon of the stearic acid chain, a common long-chain fatty acid. The esterification with methanol enhances its solubility and reactivity compared to the parent fatty acid, facilitating its application in various research settings. In scientific studies, Methyl 12-hydroxystearate is extensively used to investigate the physicochemical properties of lipid derivatives, particularly how the introduction of a hydroxyl group influences lipid behavior and interactions. This modified lipid is crucial for studying the dynamics of lipid membranes, including their phase transitions, fluidity, and interaction with other lipophilic substances. Its structure allows researchers to explore the balance between hydrophilicity and hydrophobicity in lipid molecules, which is essential for understanding the assembly and stability of lipid-based structures like micelles and vesicles. Additionally, Methyl 12-hydroxystearate serves as a model compound in the study of lipid oxidation and polymerization reactions, providing insights into the stability and degradation mechanisms of hydroxylated fatty acids under various conditions. This research has broader implications, including the development of bio-based materials and environmentally friendly lubricants and coatings, where such modified lipids play a pivotal role.


Methyl 12-hydroxystearate (CAS 141-23-1) References

  1. Preparation and properties of gem-dichlorocyclopropane derivatives of long-chain fatty esters.  |  Jie, MS. and Wong, CF. 1992. Lipids. 27: 59-64. PMID: 1608306
  2. The GLC and TLC resolution of diastereoisomeric polyhydroxystearates and assignment of configurations.  |  Wood, R., et al. 1966. Lipids. 1: 399-408. PMID: 17805647
  3. Lipase-catalyzed synthesis and properties of poly[(12-hydroxydodecanoate)-co-(12-hydroxystearate)] directed towards novel green and sustainable elastomers.  |  Ebata, H., et al. 2008. Macromol Biosci. 8: 38-45. PMID: 17955511
  4. Allergic contact dermatitis to methyl hydroxystearate in a rubber respirator.  |  Benton, EC., et al. 2012. Contact Dermatitis. 67: 238-9. PMID: 22957486
  5. Synthesis and evaluation of antioxidant and antifungal activities of novel ricinoleate-based lipoconjugates of phenolic acids.  |  Reddy, KK., et al. 2012. Food Chem. 134: 2201-7. PMID: 23442675
  6. Stimulation of nitrogen removal in the rhizosphere of aquatic duckweed by root exudate components.  |  Lu, Y., et al. 2014. Planta. 239: 591-603. PMID: 24271005
  7. Chemical Changes of Hydroperoxy-, Epoxy-, Keto- and Hydroxy-Model Lipids under Simulated Gastric Conditions.  |  Márquez-Ruiz, G., et al. 2021. Foods. 10: PMID: 34574145
  8. Fatty acids. part 42 The preparation and properties of methyl monomercaptostearates. some related thiols, and some methyl epithiostearates.  |  Gunstone, FD., et al. 1974. Chem Phys Lipids. 13: 71-91. PMID: 4413446
  9. NMR chemical shift reagents in structural determination of lipid derivatives. 3. Methyl ricinoleate and methyl 12-hydroxystearate.  |  Wineburg, JP. and Swern, D. 1973. J Am Oil Chem Soc. 50: 142-6. PMID: 4710939
  10. Investigation of fatty acids and derivatives for carcinogenic activity.  |  Swern, D., et al. 1970. Cancer Res. 30: 1037-46. PMID: 5504346

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl 12-hydroxystearate, 500 mg

sc-215317A
500 mg
$160.00

Methyl 12-hydroxystearate, 1 g

sc-215317
1 g
$190.00

Methyl 12-hydroxystearate, 2.5 g

sc-215317B
2.5 g
$340.00

Methyl 12-hydroxystearate, 5 g

sc-215317C
5 g
$550.00