Molecular structure of Methotrexate-methyl-d3, Dimethyl Ester, CAS Number: 432545-60-3
Methotrexate-methyl-d3, Dimethyl Ester (CAS 432545-60-3)
Alternate Names:
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid-d3 Dimethyl Ester
Application:
Methotrexate-methyl-d3, Dimethyl Ester is a deuterated esterified folic acid antagonist
CAS Number:
432545-60-3
Molecular Weight:
485.51
Molecular Formula:
C22H23D3N8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methotrexate-methyl-d3 is a deuterated esterified form of Methotrexate which is an antineoplastic and antirheumatic agent. Studies indicate that Methotrexate-methyl-d3 can act as a folic acid (sc-204758) antagonist. Methotrexate competitively and irreversibly inhibits DHFR (dihydrofolate reductase) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that Methotrexate-methyl-d3 can suppress T cell activation and adhesion molecule expression through IL-1 suppression..
Inhibitor of:
DHFR, and IL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methotrexate-methyl-d3, Dimethyl Ester, 2.5 mg | sc-218708 | 2.5 mg | $330.00 |