Molecular structure of Methotrexate-methyl-d3, CAS Number: 432545-63-6
Methotrexate-methyl-d3 (CAS 432545-63-6)
See product citations (10)
Application:
Methotrexate-methyl-d3 is a deuterated folic acid antagonist
CAS Number:
432545-63-6
Molecular Weight:
457.47
Molecular Formula:
C20H19D3N8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methotrexate-methyl-d3 is a deuterated Methotrexate which is an antineoplastic and antirheumatic agent. Studies indicate that Methotrexate-methyl-d3 can act as a folic acid (sc-204758) antagonist. Methotrexate competitively inhibits DHFR (dihydrofolate reductase) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that Methotrexate-methyl-d3 can suppress T cell activation and adhesion molecule expression.
Methotrexate-methyl-d3 (CAS 432545-63-6) References
- The fluorometric measurement of the absorption, distribution and excretion of single doses of 4-amino-10-methyl pteroylglutamic acid (amethopterin) in man. | FREEMAN, MV. 1958. J Pharmacol Exp Ther. 122: 154-62. PMID: 13502840
- Aerobic activated sludge transformation of methotrexate: identification of biotransformation products. | Kosjek, T., et al. 2015. Chemosphere. 119 Suppl: S42-50. PMID: 24835159
- A surface wipe sampling and LC-MS/MS method for the simultaneous detection of six antineoplastic drugs commonly handled by healthcare workers. | Jeronimo, M., et al. 2015. Anal Bioanal Chem. 407: 7083-92. PMID: 26141324
- Wipe Sampling Method and Evaluation of Environmental Variables for Assessing Surface Contamination of 10 Antineoplastic Drugs by Liquid Chromatography/Tandem Mass Spectrometry. | Colombo, M., et al. 2017. Ann Work Expo Health. 61: 1003-1014. PMID: 29028255
- Efficacy of low-dose methotrexate in rheumatoid arthritis. | Weinblatt, ME., et al. 1985. N Engl J Med. 312: 818-22. PMID: 3883172
Inhibitor of:
DHFR, and IL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methotrexate-methyl-d3, 5 mg | sc-218707 | 5 mg | $700.00 |