Methotrexate-methyl-d3 CAS: 432545-63-6
MF: C20H19D3N8O5
MW: 457.46
A deuterated folic acid antagonist.

Methotrexate-methyl-d3 (CAS 432545-63-6)

Methotrexate-methyl-d3 | CAS 432545-63-6 is rated 5.0 out of 5 by 1.
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Alternate Names: Methotrexate-d3
Application: Methotrexate-methyl-d3 is a deuterated folic acid antagonist
CAS Number: 432545-63-6
Molecular Weight: 457.46
Molecular Formula: C20H19D3N8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Methotrexate-methyl-d3 is a deuterated form of methotrexate, an antineoplastic and antirheumatic agent. Studies indicate that methotrexate-methyl-d3 can act as a folic acid (sc-204758) antagonist. Methotrexate competitively and irreversibly inhibits dihydrofolate reductase (DHFR) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that methotrexate-methyl-d3 can suppress T cell activation and adhesion molecule expression through IL-1 suppression.


References

1. Freeman, M.V., et al. 1958. J. Pharmacol. Exp. Ther., 122: 154-162. PMID: 13502840
2. Weinblatt, M.E., et al. 1985. N. Engl. J. Med. 312: 818-822. PMID: 3883172

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
12312806
SMILES :
[2H]C([2H])([2H])N(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Methotrexate-methyl-d3 (CAS 432545-63-6)  Product Citations

See how others have used Methotrexate-methyl-d3 (CAS 432545-63-6). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 29028255  Colombo, M.|Jeronimo, M.|Astrakianakis, G.|Apte, C.|Hon, CY.| et al. 2017. Ann Work Expo Health. 61: 1003-1014.

PMID: # 26971211  Ferre-Aracil, J. et al. 2016. The Science of the total environment. 556: 70-9.

PMID: # 27814544  Isidori, M. et al. 2016. Environ. Pollut. 219: 275-287.

PMID: # 26141324  Jeronimo, M. et al. 2015. Analytical and bioanalytical chemistry. 407: 7083-92.

PMID: # 24835159  Kosjek, T. et al. 2015. Chemosphere. 119 Suppl: S42-50.

PMID: # 25124055  Negreira, N. et al. 2014. Sci. Total Environ. 497-498: 68-77.

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 23456770  Liu, DY. et al. 2013. Biopharm Drug Dispos. 34: 203-14.

PMID: # 23357749  Negreira, N. et al. 2013. J Chromatogr A. 1280: 64-74.

PMID: # 29558725  J Pharm Biomed Anal. 245-251.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Meesters Meesters, RJ. et al. (PubMed 21679031) presented a new analytical MS method using isotope dilution combined with MALDI-triple quadrupole MS/MS for the determination of methotrexate and 7-hydroxymethotrexate in plasma. Methotrexate, Methotrexate-d3, 7-hydroxymethotrexate and 7-hydroxymethotrexate-d3 were monitored by selected reaction monitoring using the transitions m/z 455.2 308.2, 458.2 311.2, 471.2 324.2 and 474.2 327.2 for methotrexate, Methotrexate-d3, 7-hydroxymethotrexate and 7-hydroxymethotrexate-d3, respectively. -SCBT Publication Review
Date published: 2015-01-14
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