Methotrexate Dimethyl Ester (CAS 34378-65-9)
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Methotrexate Dimethyl Ester is an analog of methotrexate used predominantly in biochemical and pharmacological research. As a compound with a structure closely related to the parent molecule, it provides a useful comparison in studies aimed at understanding the molecular basis of methotrexate′s mechanism of action, which involves the inhibition of the enzyme dihydrofolate reductase (DHFR). Researchers employ this ester form to investigate the enzyme′s binding affinity and the subsequent effects on folate metabolism within cells. The altered ester group in its structure allows scientists to explore the impact of molecular modifications on bioactivity and stability, offering insights into potential modifications that could alter the interaction with biological targets.
Methotrexate Dimethyl Ester (CAS 34378-65-9) References
- Identification of impurities in methotrexate drug substances using high-performance liquid chromatography coupled with a photodiode array detector and Fourier transform ion cyclotron resonance mass spectrometry. | Wu, CS., et al. 2013. Rapid Commun Mass Spectrom. 27: 971-8. PMID: 23592199
- Ligand exchange on gold nanoparticles for drug delivery and enhanced therapeutic index evaluated in acute myeloid leukemia models. | Egusa, S., et al. 2014. Exp Biol Med (Maywood). 239: 853-861. PMID: 24879424
- Cross resistance to esters of methotrexate in a doxorubicin-resistant subline of P388 murine leukemia. | Ramu, A., et al. 1985. Cancer Chemother Pharmacol. 15: 31-4. PMID: 4006047
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methotrexate Dimethyl Ester, 250 mg | sc-218706 | 250 mg | $317.00 |