Molecular structure of Methimepip dihydrobromide, CAS Number: 151070-80-3
Methimepip dihydrobromide (CAS 151070-80-3)
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Application:
Methimepip dihydrobromide is a selective histamine H3 receptor agonist
CAS Number:
151070-80-3
Purity:
≥98%
Molecular Weight:
341.09
Molecular Formula:
C10H17N3•2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Extremely selective histamine H3 receptor agonist (pKi values are 9.0, 5.7, < 5.0 and < 5.0 for hH3, hH4, hH1 and hH2 receptors respectively). Potently inhibits EFS-evoked contractions of guinea pig ileum (pD2 = 8.26).
Methimepip dihydrobromide (CAS 151070-80-3) References
- Regulation of ERK2 phosphorylation by histamine in splenocytes. | Dandekar, RD. and Khan, MM. 2011. Immunopharmacol Immunotoxicol. 33: 250-8. PMID: 21554104
- Involvement of histamine receptors in SAPK/JNK phosphorylation. | Dandekar, RD. and Khan, MM. 2012. Int Immunopharmacol. 13: 190-6. PMID: 22487127
- Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. | Chen, Y., et al. 2016. Sci Signal. 9: ra74. PMID: 27460988
- Histamine H4 receptor mediates chemotaxis of human lung mast cells. | Kay, LJ., et al. 2018. Eur J Pharmacol. 837: 38-44. PMID: 30148998
Activator of:
Histamine H1 Receptor, Histamine H2 Receptor, Histamine H3 Receptor, and Histamine H4 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methimepip dihydrobromide, 10 mg | sc-204080 | 10 mg | $155.00 | |||
Methimepip dihydrobromide, 50 mg | sc-204080A | 50 mg | $670.00 |