Date published: 2026-4-29

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Methidathion (CAS 950-37-8)

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CAS Number:
950-37-8
Molecular Weight:
302.33
Molecular Formula:
C6H11N2O4PS3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methidathion, a long-standing organophosphate insecticide, has been utilized for decades to combat a diverse array of insect pests. What sets it apart is its broad-spectrum effectiveness, proving to be potent against various insect species, including those resistant to other insecticides. Its versatility extends to multiple formulations, such as liquids, granules, and wettable powders, catering to its use in agricultural, horticultural, and home gardening applications. Scientific research has extensively investigated Methidathion, shedding light on its impact on mammals, birds, and aquatic organisms, as well as its potential for causing environmental contamination. Its efficacy in controlling insect pests and its ability to tackle insect resistance have also been subjects of keen study. The mechanism of Methidathion′s action revolves around inhibiting the enzyme acetylcholinesterase, which plays a pivotal role in transmitting nerve signals. With this enzyme blocked, the transmission of nerve signals is disrupted, leading to paralysis and eventual demise of the targeted insects.


Methidathion (CAS 950-37-8) References

  1. Fate of methidathion residues in biological waste during anaerobic digestion.  |  Vorkamp, K., et al. 2002. Chemosphere. 48: 287-97. PMID: 12146617
  2. A case of fatal trichlorfon and methidathion poisoning.  |  Arao, T., et al. 2002. Leg Med (Tokyo). 4: 182-6. PMID: 12935667
  3. Monooxygenase activity in methidathion resistant and susceptible populations of Amblyseius womersleyi (Acari: Phytoseiidae).  |  Sato, ME., et al. 2006. Exp Appl Acarol. 39: 13-24. PMID: 16680563
  4. Effects of glyphosate and methidathion on the expression of the Dhb, Vtg, Arnt, CYP4 and CYP314 in Daphnia magna.  |  Le, TH., et al. 2010. Chemosphere. 79: 67-71. PMID: 20096918
  5. Methidathion: S-(5-meth-oxy-2-oxo-2,3-dihydro-1,3,4-thia-diazol-3-yl)methyl O,O-dimethyl phospho-rodithio-ate.  |  Kim, H., et al. 2011. Acta Crystallogr Sect E Struct Rep Online. 67: o653. PMID: 21522405
  6. Evaluation of the carcinogenic potential of pesticides. 2. Methidathion.  |  Quest, JA., et al. 1990. Regul Toxicol Pharmacol. 12: 117-26. PMID: 2259753
  7. High concentration of methidathion detected in a fatal case of organophosphate-poisoning.  |  Takayasu, T., et al. 2012. Leg Med (Tokyo). 14: 263-6. PMID: 22704879
  8. Electrochemical impedimetric sensor based on molecularly imprinted polymers/sol-gel chemistry for methidathion organophosphorous insecticide recognition.  |  Bakas, I., et al. 2014. Talanta. 130: 294-8. PMID: 25159412
  9. Determination of genotoxic effects of methidathion alkaline hydrolysis in human lymphocytes using the micronucleus assay and square-wave voltammetry.  |  Stivaktakis, PD., et al. 2017. Bioelectrochemistry. 113: 9-14. PMID: 27607473
  10. 1H-NMR-based metabolomic study on toxicity of methomyl and methidathion in fish.  |  Yoon, D., et al. 2016. J Environ Sci Health B. 51: 824-831. PMID: 27715651
  11. An alternative purification method for human serum paraoxonase 1 and its interaction with methidathion.  |  Gençer, N. and Yavuz, E. 2017. Arch Physiol Biochem. 123: 159-164. PMID: 28276711
  12. Methidathion Poisoning.  |  Kim, KH., et al. 2017. Korean J Crit Care Med. 32: 363-369. PMID: 31723659
  13. Medicolegal implication of an autopsy case of methidathion ingestion.  |  Naoko, T., et al. 2019. Soud Lek. 64: 42-43. PMID: 31842549
  14. Post-mortem interaction between methidathion and human serum albumin in blood.  |  Yamagishi, Y., et al. 2022. J Toxicol Sci. 47: 139-146. PMID: 35370241

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methidathion, 100 mg

sc-250317
100 mg
$32.00