Molecular structure of Methicillin Sodium Salt
Methicillin Sodium Salt (CAS 132-92-3)
Alternate Names:
Sodium (2,6-dimethoxyphenyl)penicillin; Sodium methicillin
Application:
Methicillin Sodium Salt is a semi-synthetic antibiotic related to penicillin
CAS Number:
132-92-3
Purity:
≥85%
Molecular Weight:
402.39
Molecular Formula:
C17H19N2O6S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methicillin Sodium Salt is a narrow spectrum beta-lactam antibiotic in the penicillin family. beta-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP′s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.
Methicillin Sodium Salt (CAS 132-92-3) References
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- Disseminated methicillin-susceptible Staphylococcus aureus infection. | Perkins, DR., et al. 2018. J Med Microbiol. 67: 83-86. PMID: 29154747
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- Methicillin resistance genes and in vitro biofilm formation among Staphylococcus aureus isolates from bovine mastitis in India. | Shah, MS., et al. 2019. Comp Immunol Microbiol Infect Dis. 64: 117-124. PMID: 31174686
- Interventions to treat methicillin-susceptible Staphylococcus aureus bacteremia: many methodological concerns. | García-Perdomo, HA. and Toro Maldonado, JF. 2019. BMC Infect Dis. 19: 892. PMID: 31653196
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- Methicillin-susceptible staphylococcus aureus in community-acquired pneumonia: Risk factors and outcomes. | Cilloniz, C., et al. 2021. J Infect. 82: 76-83. PMID: 33144192
- Antimicrobial Wound Dressings against Fluorescent and Methicillin-Sensitive Intracellular Pathogenic Bacteria. | Garcia-Salinas, S., et al. 2020. ACS Appl Mater Interfaces. 12: 51302-51313. PMID: 33147946
- Vescalagin and Castalagin Present Bactericidal Activity toward Methicillin-Resistant Bacteria. | Araújo, AR., et al. 2021. ACS Biomater Sci Eng. 7: 1022-1030. PMID: 33596039
- Elasnin Effectively Eradicates Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Biofilms. | Sulaiman, JE., et al. 2022. Microbiol Spectr. 10: e0232021. PMID: 35196789
- Methicillin resistance in Staphylococcus aureus modulates the transcriptome and disease pathology in a murine model of endophthalmitis. | Naik, P., et al. 2022. Exp Eye Res. 218: 109016. PMID: 35257714
- Ceftriaxone versus cefazolin for the treatment of methicillin-susceptible Staphylococcus aureus bacteraemia. | Mohamed, A., et al. 2022. Int J Antimicrob Agents. 60: 106632. PMID: 35787919
- Post-treatment outcomes of ceftriaxone versus antistaphylococcal penicillins or cefazolin for definitive therapy of methicillin-susceptible Staphylococcus aureus bacteremia. | Yetmar, ZA., et al. 2023. Eur J Clin Microbiol Infect Dis. 42: 423-430. PMID: 36800065
- Virulent potential of methicillin-resistant and methicillin-susceptible Staphylococcus pseudintermedius in dogs. | Breyer, GM., et al. 2023. Acta Trop. 242: 106911. PMID: 36965612
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methicillin Sodium Salt, 50 mg | sc-394118 | 50 mg | $92.00 |