Methazolamide (CAS 554-57-4)
See product citations (3)
QUICK LINKS
Methazolamide functions as a carbonic anhydrase inhibitor, targeting the enzymatic activity of carbonic anhydrase isoforms prevalent in various tissues, including the eye and renal system. By inhibiting this enzyme, methazolamide reduces the formation of bicarbonate ions, leading to a decrease in fluid transport and secretion. Modulation of ion and fluid transport is necessary to study physiological processes. The inhibition properties of methazolamide are utilized in studies focused on understanding ionic balance and fluid dynamics, providing valuable insights into the underlying biology of cellular transport systems. Its role in altering the pH balance within cells and tissues makes it useful in experimental setups investigating the effects of acid-base homeostasis in various biological scenarios.
Methazolamide (CAS 554-57-4) References
- Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. | Wang, X., et al. 2009. Stroke. 40: 1877-85. PMID: 19299628
- Methazolamide does not impair respiratory work performance in anesthetized rabbits. | Kiwull-Schöne, HF., et al. 2009. Am J Physiol Regul Integr Comp Physiol. 297: R648-54. PMID: 19553495
- The metabolism of methazolamide - identification of metabolites in guinea pig urine. | Kishida, K., et al. 2011. Drug Metab Lett. 5: 45-54. PMID: 21198437
- Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo. | Konstantopoulos, N., et al. 2012. Diabetes. 61: 2146-54. PMID: 22586591
- Optimization of methazolamide-loaded solid lipid nanoparticles for ophthalmic delivery using Box-Behnken design. | Wang, F., et al. 2014. J Liposome Res. 24: 171-81. PMID: 24611687
- The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain. | Fossati, S., et al. 2016. Neurobiol Dis. 86: 29-40. PMID: 26581638
- Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice. | Li, M., et al. 2016. Sci Rep. 6: 35055. PMID: 27731352
- The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells. | Sasabe, T., et al. 2017. Drug Metab Lett. 10: 295-305. PMID: 28137210
- CD8+ T-cell activation by methazolamide causes methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. | Jee, YK., et al. 2017. Clin Exp Allergy. 47: 972-974. PMID: 28295713
- Therapeutic Efficacy of Methazolamide Against Intermittent Hypoxia-Induced Excessive Erythrocytosis in Rats. | Zhang, Z., et al. 2018. High Alt Med Biol. 19: 69-80. PMID: 29077517
- Association between HLA-B*5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis. | Tangamornsuksan, W. and Lohitnavy, M. 2019. Pharmacogenomics J. 19: 286-294. PMID: 30242287
- Methazolamide Attenuates the Development of Diabetic Cardiomyopathy by Promoting β-Catenin Degradation in Type 1 Diabetic Mice. | Chen, X., et al. 2022. Diabetes. 71: 795-811. PMID: 35043173
- Detection, identification, characterization, and high-performance liquid chromatography quantification of five impurities from a methazolamide product. | Shen, Q., et al. 2022. J Sep Sci. 45: 3128-3138. PMID: 35691018
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methazolamide, 1 g | sc-235615 | 1 g | $94.00 |