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Methane disulfonic acid (CAS 503-40-2)

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Alternate Names:
Methanedisulphonic acid
Application:
Methane disulfonic acid is used in esterification
CAS Number:
503-40-2
Molecular Weight:
176.17
Molecular Formula:
CH4O6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methane disulfonic acid is a versatile organic acid widely employed in scientific research for its distinctive characteristics. With a pKa of -1.5, it exhibits strong acidity and serves as a flexible reagent across various reactions. Moreover, it plays a significant role as a constituent in numerous natural products and has found utility in synthesizing diverse compounds. Methane disulfonic acid has demonstrated its efficacy in a wide range of scientific research applications, including organic synthesis, organic reaction catalysis, and biochemical studies as a buffering agent. Furthermore, this acid has proven valuable in exploring enzyme kinetics and protein-ligand interactions.


Methane disulfonic acid (CAS 503-40-2) References

  1. The evaluation and comparison of trigonal and linear tricationic ion-pairing reagents for the detection of anions in positive mode ESI-MS.  |  Warnke, MM., et al. 2009. J Am Soc Mass Spectrom. 20: 529-38. PMID: 19110441
  2. Reversible inhibition of anion exchange in human erythrocytes by an inorganic disulfonate, tetrathionate.  |  Deuticke, B., et al. 1978. J Membr Biol. 44: 135-58. PMID: 731685
  3. Some Electrochemical Properties of Strong Organic Acids for Use as Fuel Cell Electrolytes: Methane Sulfonic, Methane Di‐sulfonic, Trichloroacetic, Chloro‐Difluoroacetic, Pentafluoropropanoic, Benzoic, and Benzene Sulfonic Acids  |  Rebert, N., Ateya, B. G., Poweigha, T., & Austin, L. G. 1980. Journal of The Electrochemical Society. 127(12): 2641.
  4. Mechanism of degradation of the investigational cytotoxic agent, cyclodisone (Nsc-348948)  |  Umprayn, K., Waugh, W., & Stella, V. J. 1990. International journal of pharmaceutics. 66(1-3): 253-262.
  5. Charge-Density Study of Methane Di(triimido)sulfonic Acid H2C{S(NtBu)2(NHtBu)}2-the NR Analogue of H2C{S(O)2(OH)}2  |  Leusser, D., Walfort, B., & Stalke, D. 2002. Angewandte Chemie International Edition. 41(12): 2079-2082.
  6. The Influence of Conservation Treatments and Environmental Storage Factors on Corrosion of Copper Alloys in the Ancient Athenian Agora  |  Paterakis, A. B. 2003. Journal of the American Institute for Conservation. 42(2): 313-339.
  7. Methane oxidation to acetic acid catalyzed by Pd2+ cations in the presence of oxygen  |  Zerella, M., Kahros, A., & Bell, A. T. 2006. Journal of Catalysis. 237(1): 111-117.
  8. Pt-catalyzed oxidative carbonylation of methane to acetic acid in sulfuric acid  |  Zerella, M., & Bell, A. T. 2006. Journal of Molecular Catalysis A: Chemical. 259(1-2): 296-301.
  9. 3,5-Dimethylpyrazole promoted sulfonation of acetic anhydride by H2SO4 to sulfoacetic acid and methanedisulfonic acid, and crystal structures of the complexes with Co2+, Zn2+, Ba2+, Pb2+ and Cs+  |  Jianrattanasawat, S., & Mezei, G. 2012. Inorganica Chimica Acta. 384: 318-323.
  10. Tripodal methanetrisulfonate ligands in the trinuclear complex {Ni3[CH(SO3)3]2(NMP)8}  |  Gudenschwager, M., Christoffers, J., & Wickleder, M. S. 2019. Zeitschrift für Naturforschung B. 74(1): 27-31.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methane disulfonic acid, 1 g

sc-357373
1 g
$50.00

Methane disulfonic acid, 25 g

sc-357373A
25 g
$150.00