Date published: 2026-4-30

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Methamidophos (CAS 10265-92-6)

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Alternate Names:
O,S-Dimethyl phosphoramidothioate
CAS Number:
10265-92-6
Molecular Weight:
141.13
Molecular Formula:
C2H8NO2PS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methamidophos is an insecticide belonging to the class of organophosphates. It acts as a cholinesterase inhibitor, impeding the function of the enzyme acetylcholinesterase. Its application is aimed at managing various insect pests like aphids, thrips, and whiteflies. Methamidophos also serves as useful in scientific research for investigating the consequences of cholinesterase inhibition on the nervous system. Additionally, it aids in exploring the impacts of organophosphates on insects and other invertebrates.


Methamidophos (CAS 10265-92-6) References

  1. Methamidophos transiently inhibits neuronal nicotinic receptors of rat substantia nigra dopaminergic neurons via open channel block.  |  Di Angelantonio, S., et al. 2004. Neurosci Lett. 369: 208-13. PMID: 15464266
  2. Titanium dioxide mediated photocatalytic degradation of methamidophos in aqueous phase.  |  Wei, L., et al. 2009. J Hazard Mater. 164: 154-60. PMID: 18783883
  3. Degradation of methamidophos by Hyphomicrobium species MAP-1 and the biochemical degradation pathway.  |  Wang, L., et al. 2010. Biodegradation. 21: 513-23. PMID: 19960233
  4. Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry.  |  Tacal, O. and Lockridge, O. 2010. J Appl Toxicol. 30: 469-75. PMID: 20229498
  5. Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior.  |  Lima, CS., et al. 2013. Toxicol Sci. 134: 125-39. PMID: 23596261
  6. Methamidophos alters sperm function and DNA at different stages of spermatogenesis in mice.  |  Urióstegui-Acosta, M., et al. 2014. Toxicol Appl Pharmacol. 279: 391-400. PMID: 24998973
  7. Methamidophos induces cytotoxicity and oxidative stress in human peripheral blood mononuclear cells.  |  Ramirez-Vargas, MA., et al. 2017. Environ Toxicol. 32: 147-155. PMID: 26589457
  8. Developmental Neurotoxicity of Methamidophos in the Embryo-Larval Stages of Zebrafish.  |  He, X., et al. 2016. Int J Environ Res Public Health. 14: PMID: 28036051
  9. Methamidophos, an Organophosphorus Insecticide, Induces Pro-aggressive Behaviour in Mice.  |  do Nascimento, CP., et al. 2017. Neurotox Res. 32: 398-408. PMID: 28540662
  10. Methamidophos Influences Midgut Proteinase Activity and Subcellular Structures in the Wolf Spider Pardosa pseudoamulata (Araneae: Lycosidae).  |  Wang, J., et al. 2019. J Econ Entomol. 112: 335-340. PMID: 30321348
  11. Short- and long-term exposure to methamidophos impairs spermatogenesis in mice.  |  Carvalho, RK., et al. 2020. Reprod Biol. 20: 357-364. PMID: 32405287
  12. Simultaneous degradation of triazophos, methamidophos and carbofuran pesticides in wastewater using an Enterobacter bacterial bioreactor and analysis of toxicity and biosafety.  |  Zhang, Y., et al. 2020. Chemosphere. 261: 128054. PMID: 33113645
  13. The Role of Brain Methamidophos in Acephate Poisoning in Mice.  |  Tanaka, T., et al. 2021. J UOEH. 43: 197-203. PMID: 34092764

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methamidophos, 100 mg

sc-235607
100 mg
$82.00