Molecular structure of Metastin (45-54), CAS Number: 374675-21-5
Metastin (45-54) (CAS 374675-21-5)
See product citations (2)
Application:
Metastin (45-54) is a potent and selective agonist of AXOR12 and hOT7T175
CAS Number:
374675-21-5
Molecular Weight:
1302.45
Molecular Formula:
C63H83N17O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Metastin (45-54) is a decapeptide fragment of the larger protein hormone kisspeptin, which is known for its role in regulating reproductive hormone signaling. In research, this peptide is utilized to study its interaction with the G-protein coupled receptor GPR54, an interaction that is fundamental to the onset of puberty and maintenance of reproductive health. Scientists use Metastin (45-54) to explore signal transduction pathways and to understand the intracellular mechanisms that underlie hormone secretion in response to kisspeptin. This research has broader implications for understanding fertility and associated disorders. Additionally, Metastin (45-54) provides a tool for researchers investigating the role of kisspeptin-GPR54 signaling in cell migration and metastasis, offering potential insights into the mechanisms of cancer cell behavior.
Metastin (45-54) (CAS 374675-21-5) References
- Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. | Ohtaki, T., et al. 2001. Nature. 411: 613-7. PMID: 11385580
- AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. | Muir, AI., et al. 2001. J Biol Chem. 276: 28969-75. PMID: 11387329
- The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. | Kotani, M., et al. 2001. J Biol Chem. 276: 34631-6. PMID: 11457843
- Metastin suppresses the motility and growth of CHO cells transfected with its receptor. | Hori, A., et al. 2001. Biochem Biophys Res Commun. 286: 958-63. PMID: 11527393
- Metastin-like immunoreactivity in the rat medulla oblongata and spinal cord. | Dun, SL., et al. 2003. Neurosci Lett. 335: 197-201. PMID: 12531466
- Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta. | Terao, Y., et al. 2004. Biochim Biophys Acta. 1678: 102-10. PMID: 15157736
- Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity. | Niida, A., et al. 2006. Bioorg Med Chem Lett. 16: 134-7. PMID: 16242330
- Role of metastin in the release of gonadotropin-releasing hormone from the hypothalamus of the male rat. | Nazian, SJ. 2006. J Androl. 27: 444-9. PMID: 16339453
- Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. | Lee Motoyama, JP., et al. 2007. Biochem Biophys Res Commun. 357: 828-33. PMID: 17448443
- Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. | d'Anglemont de Tassigny, X., et al. 2008. Endocrinology. 149: 3926-32. PMID: 18450966
- Effects of a KiSS-1 peptide, a metastasis suppressor gene, on the invasive ability of renal cell carcinoma cells through a modulation of a matrix metalloproteinase 2 expression. | Yoshioka, K., et al. 2008. Life Sci. 83: 332-8. PMID: 18644390
- Trypsin resistance of a decapeptide KISS1R agonist containing an Nω-methylarginine substitution. | Asami, T., et al. 2012. Bioorg Med Chem Lett. 22: 6328-32. PMID: 22995619
- LC-MS/MS quantification of a neuropeptide fragment kisspeptin-10 (NSC 741805) and characterization of its decomposition product and pharmacokinetics in rats. | Liu, Z., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 926: 1-8. PMID: 23524040
- Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity. | Asami, T., et al. 2013. J Med Chem. 56: 8298-307. PMID: 24047141
- Safety Evaluation of KP-10 (Metastin 45-54) Following once Daily Intravenous Administration for 14 Days in Dog. | Terse, PS., et al. 2021. Int J Toxicol. 40: 337-343. PMID: 34126799
Activator of:
FSHβ, and GPR54.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metastin (45-54), 1 mg | sc-221883 | 1 mg | $112.00 | |||
Metastin (45-54), 20 mg | sc-221883A | 20 mg | $1457.00 | |||
Metastin (45-54), 60 mg | sc-221883B | 60 mg | $6000.00 |