Molecular structure of Metastin
Metastin
Alternate Names:
Kisspeptin-54; KiSS-1 (68-121)
Application:
Metastin is a potent and selective agonist of AXOR12 and hOT7T175
Purity:
≥95%
Molecular Weight:
5857.41
Molecular Formula:
C258H401N79O78
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Metastin, Synthetic is a KiSS-1 gene product with 54 amino-acid residues and a C-terminally amidated LRF-motif that acts as a metastasis inhibitor by G-protein-coupled receptors (GPCRs). It is reported to inhibit chemotaxis and invasion of hOT7T175-transfected CHO cells in vitro (IC50 = 50 nM).This is shown to be a potent and selective agonist of AXOR12 and hOT7T175 (a novel human GPCR). Metastin induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells. It also binds to hOT7T175 with high affinity (Ki = 340 pM, determined by competitive binding analysis).
Metastin References
- Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. | Kinoshita, M., et al. 2005. Endocrinology. 146: 4431-6. PMID: 15976058
- Role of metastin in the release of gonadotropin-releasing hormone from the hypothalamus of the male rat. | Nazian, SJ. 2006. J Androl. 27: 444-9. PMID: 16339453
- Metastin/kisspeptin and control of estrous cycle in rats. | Maeda, K., et al. 2007. Rev Endocr Metab Disord. 8: 21-9. PMID: 17377846
- Prognostic role of KiSS-1 and possibility of therapeutic modality of metastin, the final peptide of the KiSS-1 gene, in urothelial carcinoma. | Takeda, T., et al. 2012. Mol Cancer Ther. 11: 853-63. PMID: 22367780
- Metastin levels in pregnancies complicated by pre-eclampsia and their relation with disease severity. | Adali, E., et al. 2012. J Matern Fetal Neonatal Med. 25: 2671-5. PMID: 22769053
- First-trimester maternal serum metastin, placental growth factor and chitotriosidase levels in pre-eclampsia. | Madazli, R., et al. 2012. Eur J Obstet Gynecol Reprod Biol. 164: 146-9. PMID: 22770630
- Trypsin resistance of a decapeptide KISS1R agonist containing an Nω-methylarginine substitution. | Asami, T., et al. 2012. Bioorg Med Chem Lett. 22: 6328-32. PMID: 22995619
- Menstrual cyclic change of metastin/GPR54 in endometrium. | Baba, T., et al. 2015. Med Mol Morphol. 48: 76-84. PMID: 24908069
- Augmentation of Metastin/Kisspeptin mRNA Expression by the Proestrous Luteinizing Hormone Surge in Granulosa Cells of Rats: Implications for Luteinization. | Laoharatchatathanin, T., et al. 2015. Biol Reprod. 93: 15. PMID: 25995272
- Development and Validation of a Sensitive Enzymeimmunoassay for Determination of Plasma Metastin in Mithun (Bos frontalis). | Mondal, M., et al. 2016. J Immunoassay Immunochem. 37: 201-16. PMID: 26599603
- KISS1/KISS1R and Breast Cancer: Metastasis Promoter. | Guzman, S., et al. 2019. Semin Reprod Med. 37: 197-206. PMID: 31972865
- Pharmacokinetic and pharmacodynamic modeling of the metastin/kisspeptin analog, TAK-448, for its anti-tumor efficacy in a rat xenograft model. | Kogame, A., et al. 2020. Biopharm Drug Dispos. 41: 283-294. PMID: 32562504
- Safety Evaluation of KP-10 (Metastin 45-54) Following once Daily Intravenous Administration for 14 Days in Dog. | Terse, PS., et al. 2021. Int J Toxicol. 40: 337-343. PMID: 34126799
Activator of:
GPR54.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metastin, 500 µg | sc-221884 | 500 µg | $310.00 |