Metal ABC transporter substrate-binding lipoprotein Antibody (G-5): sc-398159

Metal ABC transporter substrate-binding lipoprotein Antibody (G-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Metal ABC transporter substrate-binding lipoprotein of S. equi origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Metal ABC transporter substrate-binding lipoprotein antibody (G-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Metal ABC transporter substrate-binding lipoprotein plays a crucial role in the transport of essential metal ions across the bacterial cell membrane, which is vital for the survival and pathogenicity of Streptococcus equi. Metal ABC transporter substrate-binding lipoprotein is involved in the uptake of metal substrates that are necessary for various cellular processes, including enzyme function and metabolic pathways. Understanding Metal ABC transporter substrate-binding lipoprotein function can provide insights into the mechanisms of bacterial virulence and potential therapeutic targets for treating infections caused by S. equi. Streptococcus is a large genus of Gram-positive bacteria comprising over 50 different species, classified into alpha, beta, or gamma hemolytic groups based on their hemolytic properties. S. equi, specifically, is an equine host-adapted pathogen responsible for strangles, a highly contagious disease characterized by tonsillitis and lymphadenitis of the head and neck, with symptoms such as fever, depression, and lymph node enlargement that can lead to respiratory distress. The infection is transmitted through inhalation of S. equi or direct contact with mucopurulent discharge from infected animals.

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Metal ABC transporter substrate-binding lipoprotein Antibody (G-5) References:

1. Getting to grips with strangles: an effective multi-component recombinant vaccine for the protection of horses from Streptococcus equi infection.  |  Guss, B., et al. 2009. PLoS Pathog. 5: e1000584. PMID: 19763180
2. Molecular characterisation of 'strangles' outbreaks in the UK: the use of M-protein typing of Streptococcus equi ssp. equi.  |  Ivens, PA., et al. 2011. Equine Vet J. 43: 359-64. PMID: 21492215
3. Association of Streptococcus equi with equine monocytes.  |  Mérant, C., et al. 2011. Vet Immunol Immunopathol. 143: 83-6. PMID: 21752476
4. Streptococcus equi: a pathogen restricted to one host.  |  Waller, AS., et al. 2011. J Med Microbiol. 60: 1231-1240. PMID: 21757503
5. Streptococcus equi subspecies equi infection (strangles) in horses.  |  Boyle, A. 2011. Compend Contin Educ Vet. 33: E1-7; quiz E8. PMID: 21870348
6. Antiphagocytic function of an IgG glycosyl hydrolase from Streptococcus equi subsp. equi and its use as a vaccine component.  |  Flock, M., et al. 2012. Infect Immun. 80: 2914-9. PMID: 22615244
7. Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model.  |  Rodrigues, MA., et al. 2012. Eur J Pharm Biopharm. 82: 392-400. PMID: 22841882
8. Detection of Streptococcus equi subspecies equi using a triplex qPCR assay.  |  Webb, K., et al. 2013. Vet J. 195: 300-4. PMID: 22884566

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Metal ABC transporter substrate-binding lipoprotein Antibody (G-5) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Metal ABC transporter substrate-binding lipoprotein Antibody (G-5) Specifications

Alternate Product Name: Metal ABC transporter substrate-binding lipoprotein

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-310

Epitope Target: Metal ABC transporter substrate-binding lipoprotein

Epitope Species: Streptococcus equi subsp. equi 4047

Product Reactivity/Detection: Metal ABC transporter substrate-binding lipoprotein

Species Reactivity/Detection: S. equi

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Metal ABC transporter substrate-binding lipoprotein Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin