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Met-Enkephalin (CAS 58569-55-4)

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Alternate Names:
Lupex; Methionine enkephalin
Application:
Met-Enkephalin is an endogenous pentapeptide with morphine-like activity
CAS Number:
58569-55-4
Purity:
≥95%
Molecular Weight:
573.67
Molecular Formula:
C27H35N5O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Met-Enkephalin is a pentapeptide that is of significant interest in the field of neuroscience and biochemistry for its role as a naturally occurring opioid peptide. In research, it is extensively used to study the binding and interaction of opioid peptides with opioid receptors in the brain. As a ligand for these receptors, Met-Enkephalin is involved in studies aiming to understand pain modulation, stress response, and reward pathways. Furthermore, it serves as a model peptide in the exploration of peptide-receptor dynamics, which is fundamental in elucidating signal transduction mechanisms within the central nervous system. Met-Enkephalin is also utilized in comparative studies of peptide degradation, investigating the stability of opioid peptides in biological systems and the enzymes involved in their metabolism.


Met-Enkephalin (CAS 58569-55-4) References

  1. Effects of Met-enkephalin on the mechanical activity and distribution of Met-enkephalin-like immunoreactivity in the cat large intestine.  |  Venkova, K., et al. 1992. Peptides. 13: 193-201. PMID: 1320264
  2. Met-enkephalin in the liver as a marker of hepatocellular damage in chronic viral hepatitis type B and C.  |  Cieśla, A., et al. 2006. Adv Med Sci. 51: 261-4. PMID: 17357322
  3. The proenkephalin-A-derivative Met-enkephalin-Arg-Gly-Leu is not present in the feline species.  |  Cupo, A., et al. 1990. Neuropeptides. 17: 171-6. PMID: 2093149
  4. Detection of Met-enkephalin and Leu-enkephalin in the brain of the hagfish, Eptatretus stouti, and the lamprey, Petromyzon marinus.  |  Dores, RM. and Gorbman, A. 1990. Gen Comp Endocrinol. 77: 489-99. PMID: 2338228
  5. Hepatoprotective effects of Met-enkephalin on acetaminophen-induced liver lesions in male CBA mice.  |  Martinić, R., et al. 2014. Molecules. 19: 11833-45. PMID: 25105920
  6. Smart Polymeric Nanocarriers of Met-enkephalin.  |  Szweda, R., et al. 2016. Biomacromolecules. 17: 2691-700. PMID: 27409457
  7. Isolation stress impacts Met-enkephalin in the hypothalamo-pituitary-adrenocortical axis in growing Polish Mountain sheep: a possible role of the opioids in modulation of HPA axis.  |  Pierzchała-Koziec, K., et al. 2019. Stress. 22: 256-264. PMID: 30636454
  8. Remote ischaemic preconditioning modifies serum apolipoprotein D, met-enkephalin, adenosine, and nitric oxide in healthy young adults.  |  Ng, MW., et al. 2019. Clin Exp Pharmacol Physiol. 46: 995-1000. PMID: 31361911
  9. Met-enkephalin and Met-enkephalin-Arg6-Gly7-Leu8 immunofluorescence in the developing guinea-pig organ of Corti.  |  Gil-Loyzaga, P., et al. 1988. Brain Res. 470: 142-5. PMID: 3409044
  10. Met-enkephalin-induced release into the blood of a factor causing postural asymmetry.  |  Bakalkin GYa, ., et al. 1986. Peptides. 7: 551-6. PMID: 3763433
  11. Met-enkephalin, age and anatomy: a microiontophoretic study in the hippocampus.  |  Haigler, HJ., et al. 1987. Life Sci. 40: 203-13. PMID: 3796220
  12. Occurrence of met-enkephalin, met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8 in gastrin cells of hog antral mucosa.  |  Jönsson, AC. 1985. Cell Tissue Res. 240: 361-5. PMID: 3995557
  13. Immunohistochemical studies on the gastrointestinal tract using antisera to Met-enkephalin and Met-enkephalin Arg6Phe7.  |  Bu'Lock, AJ., et al. 1983. J Histochem Cytochem. 31: 1356-62. PMID: 6355286
  14. Met- and leu-enkephalin immuno- and bio-reactivity in human stomach and pancreas.  |  Feurle, GE., et al. 1982. Life Sci. 31: 2961-9. PMID: 7162359
  15. Met-enkephalin alteration in the rat during chronic injection of morphine and/or midazolam.  |  Tejwani, GA. and Rattan, AK. 1997. Brain Res. 775: 119-26. PMID: 9439835

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Met-Enkephalin, 25 mg

sc-391915
25 mg
$220.00