Mesna-d4 (may contain up to 10% disulfide) (CAS 1189479-73-9)

Mesna-d4 (may contain up to 10% disulfide), chemically designated as sodium 2-sulfanylethanesulfonate-d4, represents a deuterated analog of Mesna, where the incorporation of deuterium atoms enhances its stability and makes it an invaluable tool in analytical and biochemical research. Its core mechanism relies on its ability to act as a scavenger of reactive metabolites, particularly in the context of protecting cellular structures from oxidative stress in vitro. By substituting hydrogen atoms with deuterium, Mesna-d4 exhibits altered pharmacokinetic properties, allowing researchers to study the metabolism and pharmacokinetic processes of sulfhydryl-containing compounds with increased precision. This unique characteristic of Mesna-d4 facilitates its role in the development and validation of analytical methods, including mass spectrometry and nuclear magnetic resonance spectroscopy, where it serves as an internal standard to ensure accurate quantification and identification of sulfhydryl-containing compounds in complex biological matrices. Through its application, scientists can dissect the intricate dynamics of sulfhydryl-dependent biochemical pathways, contributing significantly to the understanding of cellular processes that rely on the redox state and the protective mechanisms against oxidative damage.