Molecular structure of Mesembrine, CAS Number: 24880-43-1
Mesembrine (CAS 24880-43-1)
Alternate Names:
Mesembranone
Application:
Mesembrine is An alkaloid used in preparing Channa
CAS Number:
24880-43-1
Molecular Weight:
289.37
Molecular Formula:
C17H23NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Mesembrine is an alkaloid found in the plant S. tortuosum, notable for its ability to inhibit the reuptake of serotonin, a key neurotransmitter. It exhibits a strong affinity for the serotonin transporter (SERT), with significantly less interaction with other receptors. This compound has been observed to block serotonin reuptake effectively in laboratory environments. In certain studies, mesembrine was shown to produce analgesic effects. Additionally, mesembrine has been found to mildly inhibit phosphodiesterase 4 (PDE4), an enzyme. Its presence in Sceletium tortuosum, known as kanna, is suggested to be a contributing factor to some of the plant′s potential properties observed in research applications.
Mesembrine (CAS 24880-43-1) References
- A capillary zone electrophoresis method for the assay and quality control of mesembrine in Sceletium tablets. | Patnala, S. and Kanfer, I. 2008. J Pharm Biomed Anal. 48: 440-6. PMID: 18280080
- Palladium-catalyzed sequential arylation and allylic alkylation of highly functionalized ketones: a concise synthesis of mesembrine. | Zhao, Y., et al. 2009. Org Lett. 11: 555-8. PMID: 19117400
- HPLC analysis of mesembrine-type alkaloids in Sceletium plant material used as an African traditional medicine. | Patnala, S. and Kanfer, I. 2010. J Pharm Pharm Sci. 13: 558-70. PMID: 21486531
- In vitro permeation of mesembrine alkaloids from Sceletium tortuosum across porcine buccal, sublingual, and intestinal mucosa. | Shikanga, EA., et al. 2012. Planta Med. 78: 260-8. PMID: 22105579
- Forensic analysis of mesembrine alkaloids in Sceletium tortuosum by nonaqueous capillary electrophoresis mass spectrometry. | Roscher, J., et al. 2012. Electrophoresis. 33: 1567-70. PMID: 22736358
- GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high 'Kanna' isolated from Sceletium tortuosum. | Meyer, GM., et al. 2015. Anal Bioanal Chem. 407: 761-78. PMID: 25240931
- Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine™, a mesembrine-rich Sceletium extract. | Swart, AC. and Smith, C. 2016. J Ethnopharmacol. 177: 35-45. PMID: 26608706
- High-mesembrine Sceletium extract (Trimesemine™) is a monoamine releasing agent, rather than only a selective serotonin reuptake inhibitor. | Coetzee, DD., et al. 2016. J Ethnopharmacol. 177: 111-6. PMID: 26615766
- Pyrone Diels-Alder Routes to Indolines and Hydroindolines: Syntheses of Gracilamine, Mesembrine, and Δ(7) -Mesembrenone. | Gan, P., et al. 2016. Angew Chem Int Ed Engl. 55: 3625-30. PMID: 26865400
- Quantification of mesembrine and mesembrenone in mouse plasma using UHPLC-QToF-MS: Application to a pharmacokinetic study. | Manda, VK., et al. 2017. Biomed Chromatogr. 31: PMID: 27526669
- A Concise Total Synthesis of (-)-Mesembrine. | Wang, LN., et al. 2016. J Org Chem. 81: 10165-10171. PMID: 27723969
- Sarniensine, a mesembrine-type alkaloid isolated from Nerine sarniensis, an indigenous South African Amaryllidaceae, with larvicidal and adulticidal activities against Aedes aegypti. | Masi, M., et al. 2017. Fitoterapia. 116: 34-38. PMID: 27864138
- Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology. | Krstenansky, JL. 2017. J Ethnopharmacol. 195: 10-19. PMID: 27939420
Inhibitor of:
ST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mesembrine, 1 mg | sc-484336 | 1 mg | $316.00 | |||
Mesembrine, 5 mg | sc-484336A | 5 mg | $1270.00 | |||
Mesembrine, 10 mg | sc-484336B | 10 mg | $2086.00 | |||
Mesembrine, 20 mg | sc-484336C | 20 mg | $3718.00 | |||
Mesembrine, 50 mg | sc-484336D | 50 mg | $8165.00 |