Molecular structure of Merbarone, CAS Number: 97534-21-9
Merbarone (CAS 97534-21-9)
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Alternate Names:
5-(N-Phenylcarbamoyl)-2-thiobarbituric acid
CAS Number:
97534-21-9
Molecular Weight:
263.27
Molecular Formula:
C11H9N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Merbarone, alternatively referred to as Nsc-336628 or RLBN-1001. This compound triggers the activation of caspase-activated DNase, leading to the removal of chromosomal DNA loops from the nuclear matrix. Moreover, Merbarone effectively induces apoptosis in CEM cells by activating ICE/CED-3-like protease. Notably, Merbarone achieves its inhibitory effect on human topoisomerase IIalpha by hindering its DNA cleavage activity.
Merbarone (CAS 97534-21-9) References
- Merbarone, a catalytic inhibitor of DNA topoisomerase II, induces apoptosis in CEM cells through activation of ICE/CED-3-like protease. | Khélifa, T. and Beck, WT. 1999. Mol Pharmacol. 55: 548-56. PMID: 10051540
- Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187. | Wang, L. and Eastmond, DA. 2002. Environ Mol Mutagen. 39: 348-56. PMID: 12112387
- Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix. | Otake, Y., et al. 2006. Mol Pharmacol. 69: 1477-85. PMID: 16434617
- Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells. | Wang, L., et al. 2007. Mutat Res. 616: 70-82. PMID: 17174356
- Dominant lethal mutations of topoisomerase II inhibitors etoposide and merbarone in male mice: a mechanistic study. | Attia, SM. 2012. Arch Toxicol. 86: 725-31. PMID: 22207148
- The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication. | Pastor, N., et al. 2012. Mutat Res. 738-739: 45-51. PMID: 22921906
- In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. | Drake, FH., et al. 1989. Cancer Res. 49: 2578-83. PMID: 2540903
- Pharmacoinformatics analysis of merbarone binding site in human topoisomerase IIα. | Tripathi, N., et al. 2019. J Mol Graph Model. 86: 1-18. PMID: 30296751
- Merbarone: an antitumor agent entering clinical trials. | Glover, A., et al. 1987. Invest New Drugs. 5: 137-43. PMID: 3308762
- Bicyclic Basic Merbarone Analogues as Antiproliferative Agents. | Spallarossa, A., et al. 2021. Molecules. 26: PMID: 33494519
- Data of transcriptional effects of the merbarone-mediated inhibition of TOP2. | Delgado-Chaves, FM., et al. 2022. Data Brief. 44: 108499. PMID: 35983130
- Characterization of novel human leukemic cell lines selected for resistance to merbarone, a catalytic inhibitor of DNA topoisomerase II. | Kusumoto, H., et al. 1996. Cancer Res. 56: 2573-83. PMID: 8653700
- Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. | Fortune, JM. and Osheroff, N. 1998. J Biol Chem. 273: 17643-50. PMID: 9651360
Inhibitor of:
Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Merbarone, 25 mg | sc-500526 | 25 mg | $158.00 |