Molecular structure of Mepyramine maleate, CAS Number: 59-33-6
Mepyramine maleate (CAS 59-33-6)
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Application:
Mepyramine maleate is a histamine H1 receptor antagonist
CAS Number:
59-33-6
Molecular Weight:
401.46
Molecular Formula:
C21H27N3O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mepyramine is a histamine H1 receptor antagonist and binds with high affinity to G(q/11) protein. Found to be a potent inhibitor of P450 2D forms in rat hepatocytes, PAF-induced platelet aggregation in rabbits, and the histamine-induced decrease in mean arterial blood pressure brought about by pertussis toxin. Mepyramine is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. This product has been recently discovered to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.
Mepyramine maleate (CAS 59-33-6) References
- Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. | Zeng, S. and Guo, ZG. 1997. Zhongguo Yao Li Xue Bao. 18: 155-8. PMID: 10072970
- Mepyramine but not cimetidine or clobenpropit blocks pertussis toxin-induced histamine sensitization in rats. | Vleeming, W., et al. 2000. Br J Pharmacol. 129: 1801-7. PMID: 10780989
- Re-examination of [3H]mepyramine binding assay for histamine H1 receptor using quinine. | Liu, YQ., et al. 1992. Biochem Biophys Res Commun. 189: 378-84. PMID: 1449491
- Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein. | Fitzsimons, CP., et al. 2004. J Biol Chem. 279: 34431-9. PMID: 15192105
- Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. | Liu, B., et al. 2008. Neuropharmacology. 54: 629-39. PMID: 18222495
- Efficacy of mepyramine maleate treatment in dogs with angioedema. | Cingi, C., et al. 2010. Pol J Vet Sci. 13: 549-50. PMID: 21033572
- Simultaneous Determination of Dexpanthenol, Lidocaine Hydrochloride, Mepyramine Maleate and their Related Substances by a RP-HPLC Method in Topical Dosage Forms. | Doganay, A., et al. 2018. J Chromatogr Sci. 56: 903-911. PMID: 30085004
- Suppression by mepyramine maleate of the increased vascular permeability in passive cutaneous anaphylaxis in the chicken. | Pillai, AG., et al. 1988. Vet Res Commun. 12: 161-3. PMID: 3188384
- High-performance liquid chromatographic determination of mepyramine maleate, pheniramine maleate and phenylpropanolamine hydrochloride in tablets and drops. | el-Gizawy, SM. and Ahmed, Ael H. 1987. Analyst. 112: 867-9. PMID: 3619056
- The actions of cimetidine hydrochloride and mepyramine maleate in rat adjuvant arthritis. | Al-Haboubi, HA. and Zeitlin, IJ. 1982. Eur J Pharmacol. 78: 175-85. PMID: 7075670
Inhibitor of:
CYP2D6, and Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mepyramine maleate, 100 mg | sc-203629 | 100 mg | $65.00 | |||
Mepyramine maleate, 1 g | sc-203629A | 1 g | $220.00 |