Mentholglucuronic acid ammonium salt (CAS 104874-25-1)

Mentholglucuronic acid ammonium salt, a derivative of menthol modified with glucuronic acid and ammonium ions, has emerged as a valuable compound in scientific research, particularly in the fields of pharmacology, neurobiology, and sensory perception. This chemical exhibits unique properties that make it suitable for various research applications. One significant area of interest is its role in elucidating the mechanisms of menthol′s effects on sensory receptors, particularly transient receptor potential (TRP) channels. Menthol is known to activate and modulate TRP channels, particularly TRPM8, which is implicated in cold sensation and pain perception. Researchers have utilized mentholglucuronic acid ammonium salt as a molecular probe to study the structure-function relationships of TRP channels and their interactions with menthol and other ligands. Moreover, studies have investigated its potential as a tool compound for manipulating sensory perception and pain sensation in preclinical models. Additionally, mentholglucuronic acid ammonium salt has been employed in sensory neuroscience research to explore the neural circuits and signaling pathways involved in menthol-induced sensations, such as cooling and analgesia. Furthermore, research has focused on developing mentholglucuronic acid ammonium salt-based formulations for topical applications, such as creams, gels, and patches, aimed at modulating sensory responses and providing relief from pain and discomfort. Overall, the versatile applications of mentholglucuronic acid ammonium salt highlight its significance as a valuable research tool in advancing our understanding of sensory physiology and developing novel approaches for sensory modulation and pain management.