Date published: 2026-5-13

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Menaquinone 8 (CAS 523-38-6)

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Alternate Names:
Menaquinone 8 is also known as Vitamin MK-8.
Application:
Menaquinone 8 is a vitamin (prothrombogenic) from the menaquinone vitamin K2 family, with 8 isoprenoid side chains.
CAS Number:
523-38-6
Molecular Weight:
717.12
Molecular Formula:
C51H72O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Menaquinone 8, also known as MK-8, is a member of the vitamin K2 family distinguished by its isoprenoid side chain which contains eight isoprene units. It plays a role in bacterial physiology and is predominantly found in certain species of bacteria, including those from the genera Streptomyces and Bacillus. Menaquinone 8 is instrumental in the electron transport chain, facilitating the process of oxidative phosphorylation by acting as an electron carrier. This function is vital for the production of ATP, which is essential for cellular energy. In research, Menaquinone 8 is studied for its role in bacterial metabolism and its impact on the microbial production of bioactive compounds. Its presence and variation in different bacterial strains can influence the study of bacterial growth conditions and the development of fermentation technologies. Additionally, Menaquinone 8′s involvement in the redox processes within cells makes it a significant focus in the study of microbial resistance to oxidative stress.


Menaquinone 8 (CAS 523-38-6) References

  1. Equilibrium and kinetic parameters for the binding of inhibitors to the QB pocket in bacterial chromatophores: dependence on the state of QA.  |  Ginet, N. and Lavergne, J. 2001. Biochemistry. 40: 1812-23. PMID: 11327844
  2. The respiratory substrate rhodoquinol induces Q-cycle bypass reactions in the yeast cytochrome bc(1) complex: mechanistic and physiological implications.  |  Cape, JL., et al. 2005. J Biol Chem. 280: 34654-60. PMID: 16087663
  3. Menaquinone as pool quinone in a purple bacterium.  |  Schoepp-Cothenet, B., et al. 2009. Proc Natl Acad Sci U S A. 106: 8549-54. PMID: 19429705
  4. Metabolic engineering of menaquinone-8 pathway of Escherichia coli as a microbial platform for vitamin K production.  |  Kong, MK. and Lee, PC. 2011. Biotechnol Bioeng. 108: 1997-2002. PMID: 21445887
  5. Age-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8.  |  Hodges, SJ., et al. 1990. Clin Sci (Lond). 78: 63-6. PMID: 2153497
  6. Identification of Carotenoids and Isoprenoid Quinones from Asaia lannensis and Asaia bogorensis.  |  Antolak, H., et al. 2017. Molecules. 22: PMID: 28946700
  7. Description of Deinococcus populi sp. nov. from the trunk surface of a Japanese aspen tree.  |  Li, J., et al. 2018. Arch Microbiol. 200: 291-297. PMID: 29080938
  8. Deinococcus kurensis sp. nov., isolated from pond water collected in Japan.  |  Akita, H., et al. 2020. Arch Microbiol. 202: 1757-1762. PMID: 32342124
  9. Location and Conformational Ensemble of Menaquinone and Menaquinol, and Protein-Lipid Modulations in Archaeal Membranes.  |  Feng, S., et al. 2021. J Phys Chem B. 125: 4714-4725. PMID: 33913729
  10. Devosia beringensis sp. nov., isolated from surface sediment of the Bering Sea.  |  Zhang, YX., et al. 2021. Int J Syst Evol Microbiol. 71: PMID: 34435948
  11. Nocardioides panacis sp. nov., isolated from soil of a ginseng field.  |  Park, Y., et al. 2022. Int J Syst Evol Microbiol. 72: PMID: 35647794
  12. Deinococcus taeanensis sp. nov., a Radiation-Resistant Bacterium Isolated from a Coastal Dune.  |  Lee, JH., et al. 2022. Curr Microbiol. 79: 334. PMID: 36161362
  13. Deinococcus betulae sp. nov. and Deinococcus arboris sp. nov., novel bacteria isolated from bark of birch tree (Betula platyphylla).  |  Bae, S., et al. 2022. Int J Syst Evol Microbiol. 72: PMID: 36251742
  14. Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity.  |  Hugenholtz, P., et al. 1998. J Bacteriol. 180: 4765-74. PMID: 9733676

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Menaquinone 8, 100 µg

sc-215296
100 µg
$583.00