Molecular structure of Menaquinone 7, CAS Number: 2124-57-4
Menaquinone 7 (CAS 2124-57-4)
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Alternate Names:
Vitamin K2(35)
Application:
Menaquinone 7 is a vitamin K2 analog and bioactive cofactor for the carboxylation reaction of Gla-proteins.
CAS Number:
2124-57-4
Purity:
≥90%
Molecular Weight:
649.00
Molecular Formula:
C46H64O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Menaquinone 7 belongs to a class of K2-vitamin homologs originally discovered as the anti-hemorrhagic factors. It has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins, such as osteocalcin and matrix-Gla protein, which play roles in building and maintaining overall bone health. Menaquinone 7 is found in a variety of fermented foods. In vivo, it may act to inhibit aortic and myocardial calcification. In a rat model of extraosseous clacifciation, Menaquinone 7 decreased aortic alkaline phosphatase tissue concentrations.
Menaquinone 7 (CAS 2124-57-4) References
- Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells. | Katsuyama, H., et al. 2005. Int J Mol Med. 15: 231-6. PMID: 15647836
- Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. | Schurgers, LJ., et al. 2007. Blood. 109: 3279-83. PMID: 17158229
- The antiosteoporotic effects of Cheonggukjang containing vitamin k2 (menaquinone-7) in ovariectomized rats. | Wu, WJ., et al. 2014. J Med Food. 17: 1298-305. PMID: 25259841
- High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification. | Scheiber, D., et al. 2015. Nutrients. 7: 6991-7011. PMID: 26295257
- Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial). | Vossen, LM., et al. 2015. Nutrients. 7: 8905-15. PMID: 26516910
- The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. | Zwakenberg, SR., et al. 2019. Am J Clin Nutr. 110: 883-890. PMID: 31387121
- MK-7 and Its Effects on Bone Quality and Strength. | Sato, T., et al. 2020. Nutrients. 12: PMID: 32244313
- Menaquinone-7 production in engineered Escherichia coli. | Gao, Q., et al. 2020. World J Microbiol Biotechnol. 36: 132. PMID: 32737601
- Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells. | Akbulut, AC., et al. 2020. Front Cell Dev Biol. 8: 618760. PMID: 33585456
- Advances in Enhanced Menaquinone-7 Production From Bacillus subtilis. | Liao, C., et al. 2021. Front Bioeng Biotechnol. 9: 695526. PMID: 34354987
- The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 diabetes patients: a randomized clinical trial. | Karamzad, N., et al. 2022. Nutr Diabetes. 12: 15. PMID: 35365594
- Menaquinone-7 ameliorates cerebrovascular calcification-associated memory decline in aged mice. | Lee, B., et al. 2022. Life Sci. 307: 120912. PMID: 36037872
- Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. | Thijssen, HH. and Drittij-Reijnders, MJ. 1994. Br J Nutr. 72: 415-25. PMID: 7947656
- Effect of vitamin K2 (menaquinone-7) on bone metabolism in the femoral-metaphyseal tissues of normal and skeletal-unloaded rats: enhancement with zinc. | Ehara, Y., et al. 1996. Res Exp Med (Berl). 196: 171-8. PMID: 8875703
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Menaquinone 7, 1 mg | sc-218691 | 1 mg | $599.00 |