Date published: 2025-11-1

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MEN10376 (CAS 135306-85-3)

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Application:
MEN10376 is a neurokinin 2 (NK2) receptor antagonist
CAS Number:
135306-85-3
Purity:
97%
Molecular Weight:
1081.3
Molecular Formula:
C57H68N12O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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MEN10376 is a synthetic compound that belongs to the tetrahydroisoquinoline class, known for its potential influence on neurotransmitter systems, particularly dopamine receptors. The chemical structure of MEN10376 suggests its capability to modulate these receptors, which are pivotal in regulating various neurological functions such as mood, reward, and motor control. In scientific research, MEN10376 is utilized to study its binding characteristics and interaction with different subtypes of dopamine receptors. These investigations are crucial for understanding the compound′s biochemical behavior and its potential effects on neural pathways. By exploring how MEN10376 affects receptor activity, researchers can gain insights into the molecular dynamics of dopamine regulation and the role of tetrahydroisoquinoline derivatives in the central nervous system. This research is instrumental in advancing the knowledge of neurotransmitter function and interaction, which is essential for the broader field of neurochemistry and the development of future research tools, while carefully avoiding any direct or implied therapeutic applications.


MEN10376 (CAS 135306-85-3) References

  1. Characterization of the [125I]-neurokinin A binding site in the circular muscle of human colon.  |  Warner, FJ., et al. 1999. Br J Pharmacol. 127: 1105-10. PMID: 10455255
  2. [125I]His-neurokinin A binds selectively to NK2 receptors of the B-type in rat small intestine smooth muscle membranes.  |  Brown, MC., et al. 1992. Eur J Pharmacol. 227: 163-71. PMID: 1330648
  3. NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon.  |  Cao, W., et al. 2006. J Pharmacol Exp Ther. 317: 1349-55. PMID: 16554357
  4. Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human.  |  Lecci, A., et al. 2006. Auton Neurosci. 126-127: 232-49. PMID: 16616700
  5. Neurokinins enhance excitability in capsaicin-responsive DRG neurons.  |  Sculptoreanu, A. and de Groat, WC. 2007. Exp Neurol. 205: 92-100. PMID: 17362934
  6. Intraluminal acid induces oesophageal shortening via capsaicin-sensitive neurokinin neurons.  |  Paterson, WG., et al. 2007. Gut. 56: 1347-52. PMID: 17525090
  7. Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons.  |  Sculptoreanu, A., et al. 2009. Exp Neurol. 219: 562-73. PMID: 19631644
  8. The investigation into indomethacin-induced potentiation of the contractile response to antigen in ovalbumin-sensitized guinea-pig tracheas.  |  Bozkurt, TE., et al. 2012. Fundam Clin Pharmacol. 26: 332-9. PMID: 21219440
  9. Neurokinin-neurotrophin interactions in airway smooth muscle.  |  Meuchel, LW., et al. 2011. Am J Physiol Lung Cell Mol Physiol. 301: L91-8. PMID: 21515660
  10. NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathway.  |  Dér, B., et al. 2019. Am J Physiol Renal Physiol. 317: F1154-F1163. PMID: 31461351
  11. The enhancing effect of 5-HT on phasic contractions of human isolated distal ureter and the mechanisms mediating these effects.  |  Ding, N., et al. 2023. Eur J Pharmacol. 949: 175715. PMID: 37059373
  12. Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin.  |  Dougherty, PM., et al. 1994. J Neurophysiol. 72: 1464-75. PMID: 7823080
  13. Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.  |  Costello, RW., et al. 1998. Br J Pharmacol. 124: 267-76. PMID: 9641542

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MEN10376, 1 mg

sc-201172
1 mg
$111.00