Membrane Traffic Inhibitor, A5
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Membrane Traffic Inhibitor, A5 is a piperazinyl compound which is cell-permeable, that has been reported to specifically block clathrin adaptor complex AP-1-dependent traffic between endosomes and trans-Golgi network (TGN) in budding yeast. Additionally, Membrane Traffic Inhibitor, A5 has been shown to have little effect against other trafficking pathways involving endosomes and TGN. Also reported to inhibit growth of yeast cells lacking complementary GGA1/2 adaptor proteins, yet not wild-type or AP-1-deficient cells even at increased concentrations such as 300 µM. A5 apparently acts at a phase after AP-1 membrane recruitment as demonstrated by an enhanced AP-1 perinuclear localization upon A5 treatment of HeLa cells.
Membrane Traffic Inhibitor, A5 References
- Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. | Jacobsen, EJ., et al. 1999. J Med Chem. 42: 1525-36. PMID: 10229623
- Usher proteins are engaged in vesicular trafficking in human retinal pigment epithelial and fibroblasts cells. | Alapure, Bhagwat V., Marianne Hathaway, and Jennifer J. Lentz. 2016. Investigative Ophthalmology & Visual Science. 57: 255-255.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Membrane Traffic Inhibitor, A5, 10 mg | sc-353670 | 10 mg | $278.00 |