Melphalan-d8 Monohydrochloride
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Melphalan-d8 Monohydrochloride is a compound that functions as an alkylating agent in applications. Its mechanism of action involves forming covalent bonds with nucleophilic groups in DNA, leading to the inhibition of DNA replication and transcription. Melphalan-d8 Monohydrochloride induces DNA cross-linking, which interferes with the normal functioning of the DNA molecule. By disrupting the DNA structure,Melphalan-d8 Monohydrochloride can impede the proliferation of cells and ultimately lead to cell death. Its mechanism of action at the molecular level involves the alkylation of guanine bases in DNA, resulting in the formation of interstrand and intrastrand cross-links. This disrupts the genetic material′s ability to replicate and transcribe, ultimately affecting the survival and function of the targeted cells in experimental applications.
Melphalan-d8 Monohydrochloride References
- Rapid and simple flow injection analysis tandem mass spectrometric method for the quantification of melphalan in a lipid-based drug delivery system. | Mohammed-Saeid, W., et al. 2017. Rapid Commun Mass Spectrom. 31: 1481-1490. PMID: 28667829
- A rapid and sensitive LC-MS/MS method for simultaneous determination of melphalan and its monohydroxy and dihydroxy metabolites in human plasma. | Li, S., et al. 2023. J Chromatogr B Analyt Technol Biomed Life Sci. 1222: 123698. PMID: 37060813
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Melphalan-d8 Monohydrochloride, 1 mg | sc-218688 | 1 mg | $393.00 |