Molecular structure of Melengestrol acetate, CAS Number: 2919-66-6
Melengestrol acetate (CAS 2919-66-6)
Alternate Names:
17α-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione; MGA
Application:
Melengestrol acetate is the acetate sale of this antineoplastic steroidal progestin
CAS Number:
2919-66-6
Purity:
≥97%
Molecular Weight:
396.52
Molecular Formula:
C25H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Melengestrol acetate (MGA) is the acetate sale of this antineoplastic steroidal progestin. It has been used extensively in scientific research as a model compound for the study of progesterone receptors and steroid hormone action. Specifically, it is employed to investigate the effects of progesterone on the reproductive and immune systems, bone metabolism, and inflammation. Melengestrol acetate stimulates the production of growth hormone, luteinizing hormone, testosteron,e and estradiol. It also increases the activity of enzymes involved in fatty acid metabolism and glucose metabolism. In addition, Melengestrol acetate reduces inflammation and has anti-tumor effects.
Melengestrol acetate (CAS 2919-66-6) References
- The fate of trenbolone acetate and melengestrol acetate after application as growth promoters in cattle: environmental studies. | Schiffer, B., et al. 2001. Environ Health Perspect. 109: 1145-51. PMID: 11713000
- Melengestrol acetate blocks the preovulatory surge of luteinizing hormone, the expression of behavioral estrus, and ovulation in beef heifers. | Imwalle, DB., et al. 2002. J Anim Sci. 80: 1280-4. PMID: 12019616
- Basis of melengestrol acetate action as a progestin. | Perry, GA., et al. 2005. Domest Anim Endocrinol. 28: 147-61. PMID: 15713363
- Melengestrol acetate alters muscle cell proliferation in heifers and steers. | Sissom, EK., et al. 2006. J Anim Sci. 84: 2950-8. PMID: 17032788
- Melengestrol acetate implant contraception in addax (Addax Nasomaculatus) and Arabian oryx (Oryx Leucoryx). | Hall-Woods, ML., et al. 2007. Zoo Biol. 26: 299-310. PMID: 19360582
- Naturally occurring and melengestrol acetate-associated reproductive tract lesions in zoo canids. | Moresco, A., et al. 2009. Vet Pathol. 46: 1117-28. PMID: 19605907
- Melengestrol acetate enhances adipogenic gene expression in cultured muscle-derived cells. | Chung, KY. and Johnson, BJ. 2009. J Anim Sci. 87: 3897-904. PMID: 19684257
- Effects of 17α-trenbolone and melengestrol acetate on Xenopus laevis growth, development, and survival. | Finch, BE., et al. 2013. Environ Sci Pollut Res Int. 20: 1151-60. PMID: 22890510
- Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. | Tsukada, A., et al. 2013. Regul Toxicol Pharmacol. 65: 316-24. PMID: 23395687
- Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates. | Gilroy, ÈAM., et al. 2020. Environ Sci Pollut Res Int. 27: 41803-41815. PMID: 32696412
- Fungal mediated biotransformation of melengestrol acetate, and T-cell proliferation inhibitory activity of biotransformed compounds. | Javed, S., et al. 2020. Bioorg Chem. 104: 104313. PMID: 33142425
- Correction to: Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates. | Gilroy, ÈAM., et al. 2021. Environ Sci Pollut Res Int. 28: 3749. PMID: 33216304
- Melengestrol acetate contraceptive implant use in colobus monkeys (Colobus guereza): Patterns through time and differences in reproductive potential and live births. | McDonald, MM., et al. 2021. Zoo Biol. 40: 124-134. PMID: 33238048
- Low invasive estrous synchronization protocol for wild animals: an example with melengestrol acetate in brown brocket deer (Mazama gouazoubira). | Tanaka, Y., et al. 2021. Anim Reprod. 17: e20200526. PMID: 33791030
- Melengestrol acetate and norgestomet for the induction of synchronized estrus in seasonally anovular ewes. | Jabbar, G., et al. 1994. J Anim Sci. 72: 3049-54. PMID: 7759352
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Melengestrol acetate, 200 mg | sc-235585 | 200 mg | $68.00 | |||
Melengestrol acetate, 1 g | sc-235585A | 1 g | $242.00 |