Cart (0)

Melatonin (CAS 73-31-4) - chemical structure image — Molecular structure of Melatonin, CAS Number: 73-31-4

Molecular structure of Melatonin, CAS Number: 73-31-4

Melatonin (CAS 73-31-4)

Name: Melatonin | CAS 73-31-4
Brand: SCBT
SKU: sc-207848
Price: 64.0 USD
Availability: InStock

5.0(2)

Write a reviewAsk a question

See product citations (16)

Alternate Names:

Melatonine; N-Acetyl-5-methoxytryptamine; Circadin

Application:

Melatonin is a neurohormone that upregulates antioxidant enzymes and inhibits rat NOS1

CAS Number:

73-31-4

Purity:

≥99%

Molecular Weight:

232.28

Molecular Formula:

C₁₃H₁₆N₂O₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ordering Information

Product Citations

Description

Technical Information

Safety Information

SDS & Certificate of Analysis

Melatonin is an indoleamine neurohormone found across plants and animals, produced endogenously from serotonin (5-HT) and secreted in animals as a regulatory signal for synchronization of the circadian rhythm and the sleep-wake cycle. The melatonin receptor system, consisting of the MEL-1A-R, MEL-1B-R, and MT3 subtypes, demonstrates particular plasticity and modularity - antagonists such as Luzindole (sc-202700) and 2-Phenylmelatonin (sc-203466) show modification of systemic responses to the Melatonin signal without impeding activation of the receptors by Melatonin. Powerful antioxidant activity is associated with Melatonin, and it is known to provide protection to lipids, proteins, and DNA against oxidative damage. Several antioxidant enzymes are shown to be upregulated by Melatonin, including glutathione peroxidase, superoxide dismutases, and catalase. Melatonin also scavenges free radicals as a terminal antioxidant, reacting to generate stable end products and terminate radical chain reactions. Free movement through the blood-brain barrier positions Melatonin as a particularly significant endogenous antioxidant. Melatonin is a rat NOS1 (nNOS) inhibitor. Melatonin is an activator of MEL-1A-R and MEL-1B-R.

Melatonin (CAS 73-31-4) References

Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. | Reiter, RJ., et al. 2001. Ann N Y Acad Sci. 939: 200-15. PMID: 11462772
Molecular tools to study melatonin pathways and actions. | Boutin, JA., et al. 2005. Trends Pharmacol Sci. 26: 412-9. PMID: 15992934
Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. | Hardeland, R. 2005. Endocrine. 27: 119-30. PMID: 16217125
Pharmacology and function of melatonin receptors. | Dubocovich, ML. 1988. FASEB J. 2: 2765-73. PMID: 2842214
Melatonin Inhibits in Vitro Smooth Muscle Cell Inflammation and Proliferation and Atherosclerosis in Apolipoprotein E-Deficient Mice. | Li, HY., et al. 2019. J Agric Food Chem. 67: 1889-1901. PMID: 30661353
Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits. | Hao, J., et al. 2019. J Exp Clin Cancer Res. 38: 48. PMID: 30717768
Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα-dependent manner. | Ding, S., et al. 2019. J Pineal Res. 67: e12581. PMID: 31009101
Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis. | Ma, H., et al. 2020. Oxid Med Cell Longev. 2020: 9067610. PMID: 33343809
Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson's Disease. | Zheng, R., et al. 2021. J Inflamm Res. 14: 3063-3075. PMID: 34267535
Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR. | Kim, MJ., et al. 2023. Cell Death Dis. 14: 146. PMID: 36810730
Psychopharmacological effects of melatonin in mouse and rat. | Sugden, D. 1983. J Pharmacol Exp Ther. 227: 587-91. PMID: 6655558
Melatonin receptors: are there multiple subtypes? | Dubocovich, ML. 1995. Trends Pharmacol Sci. 16: 50-6. PMID: 7762083
Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates. | Hattori, A., et al. 1995. Biochem Mol Biol Int. 35: 627-34. PMID: 7773197
Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. | Dubocovich, ML., et al. 1998. FASEB J. 12: 1211-20. PMID: 9737724

Inhibitor of:

β-defensin 2, 8-hydroxyguanine, 8-OHdG, 8-oxoG DNA Lesion, Apoptosis, C1QBP, C20orf103, CKMT1B, CRY1, Cypt10, E330021D16Rik, ENDOG, Fullerene, GnRH I, Malondialdehyde, melanopsin, Metallothionein, Nitrotyrosine, NOS, NOS1, OSGIN2, RADIL, retinitis pigmentosa 1, Romo1, RORα, SMP30, STOML2, and TMEM70.

Activator of:

1700106N22Rik, 20S Proteasome β5, ABCB8, AMID, Asporin, ATAD4, ATP5D, BMAL1, BMAL2, Brp16, CART, CAT, Caytaxin, CHCHD10, CHCHD8, CHIC2, Clock, COA6, COX15, COX5a, COX7c, COX8b, CRIF1, CRY2, CST, Cyclophilin D, CYP11B1, DDAH I, DNAH8, DnaJB8, DnaJC14, DnaJC4, DnaJC8, Dokl, dolichol kinase, DOLPP1, EG436008, EG546368, EG623898, encephalopsin, ERp19, ETHE1, FANCF, FANCL, Ferrochelatase, FILIA, FUNDC1, GADD 45, GH, GH-2, GHRH, Gm906, Gm97, Gvin1, Hint2, IgE, Ksr-2, LAP1B, LCA5L, LONP1, LTrp7, MEL-1A-R, MEL-1B-R, Metaxin 2, Mfn1, Mitochondrial CysRs, Mitochondrial Topo I, MOP-3, MPV17L, MRAP, MRP-L10, MRP-L44, MRP-L45, MRP-L54, MTRNR2L1, MTRNR2L10, MTRNR2L2, MTRNR2L3, MTRNR2L4, MTRNR2L6, MTRNR2L7, Na+/K+-ATPase α1, ND4, NDUFS8, neuroglobin, neuroserpin, Nocturnin, NPAS2, Nrf1, NXNL2, OGG1, OR11L1, OX2, Oxr1, PBR, PCP-4, Per3, period, peropsin, PITRM1, PP2A-B56-β, PRX III, Rad21L1, RFRP-1, RFRP-2, RNF146, RORβ, Ros, RPE65, RPGRIP1L, SKN-1, SLC25A14, SMP30, SMUG1, SOD-1, SOD-2, SOD-3, Sptrx-1, STARS, SULT1A1, SYCE1L, TAMM41, Tim13A/B, Tim13B, TMEM70, Tom7, TTC19, TTC34, TXNDC4, ULK1, XRCC2, and XRRA1.

Ordering Information

Product Name	Catalog #	UNIT	Price	Qty	FAVORITES
Melatonin, 1 g	sc-207848	1 g	$64.00
Melatonin, 5 g	sc-207848A	5 g	$72.00
Melatonin, 25 g	sc-207848B	25 g	$214.00
Melatonin, 100 g	sc-207848C	100 g	$683.00
Melatonin, 250 g	sc-207848D	250 g	$1173.00
Melatonin, 1 kg	sc-207848E	1 kg	$3504.00

请问melatonin的纯度是HPLC级别吗，想购买作标准品用

Asked by: bofu

感谢您的提问。它不是标准品。如果您能直接拨打(+86) 021-60936350，或者发邮件到我们亚洲服务部的邮箱asia@scbio.cn我们就这个问题和其他相关问题进行更多的互动讨论，那将会很有帮助。 Thank you for your question.It's not standard.It would be helpful if you could call us directly at (+86) 021-60936350 or email our Asia Service department at asia@scbio.cn for more interactive discussions on this and other related issues.

Answered by: Zhanglong

Date published: 2025-02-20

Hello, I would like to know if Melatonin is soluble in a mix of CBD distillate (50%) and pure MCT-C8 oil.

Asked by: Juliend

Thank you for your question. Please contact your local distributor or technical service for further assistance.

Answered by: Dallas Tech Service

Date published: 2022-06-02

Hello, I want to ask for the best way to dissolve melatonin for application in plant in vitro culture, is it autoclavable with other media components ? If no, how do I prepare it and for how long could it be stored in its dissolved condition. Thank you

Asked by: Tadda

Thank you for your question. Melatonin can be dissolved in ethanol at a concentration of 10 mg/ml. We have not applied this product in plant culture. The long-term preservation recommendation is -20 degrees, and the time should not exceed half a year.

Answered by: Tech Service

Date published: 2019-11-12

Es grado Alimentario?

Asked by: Nico79

Gracias por su pregunta. Melatonin: sc-207848 no es grado alimentario. Thank you for your question. Melatonin: sc-207848 is not food grade.

Answered by: Technical Support

Date published: 2018-12-06

in which solvent we can make a solution of melatonin for its application to crop plants?

Asked by: khan anayat

Thank you for your question. We recommend dissolving Melatonin: sc-207848 with water (0.1 mg/ml), ethanol (8 mg/ml), benzene, chloroform, methanol, DMSO (50 mM), toluene or dilute aqueous acid. This product is very slightly soluble in petroleum ether. You will need to determine which solvent would work best for your specific application.

Answered by: Technical Support

Date published: 2024-10-06

Rated 5 out of 5 by Juliend from QuestionHello, I would like to know if Melatonin is soluble in a mix of CBD distillate (50%) and pure MCT-C8 oil.

Date published: 2021-04-13

Rated 5 out of 5 by SS from SinghakumarSinghakumar, R. et al. (PubMed 26366944) used Melatonin on adult C57BL/6 mice that had undergone methamphetamine (METH) induced alterations in neurogenesis and post-synaptic proteinsrelated to learning and memory functions in the hippocampus. The results showed that METH caused a decrease in neuronal phenotypes as determined by the expressions of nestin, doublecortin (DCX) and beta-III tubulin while causing an increase in glial fibrillary acidic protein (GFAP) expression. These effects could be attenuated by Melatonin pretreatment. -SCBT Publication Review

Date published: 2015-03-08

Melatonin is rated 5.0 out of 5 by 2.

Santa Cruz Animal Health is a leading provider of animal health care products. ©2025 Santa Cruz Biotechnology Inc. All Rights Reserved.
Toll-Free: (800) 457-3801 - Terms & Conditions | Privacy Policy | Legal
“Santa Cruz Animal Health”, “San Juan Ranch”, the San Juan Ranch logo, “UltraCruz”, “Supplement of Champions”, are registered trademarks of Santa Cruz Biotechnology, Inc. All other trademarks are the property of their respective owners.

Test	Specification	Results
Appearance	Off-white fine crystals	Complies
Assay	> 98.0%	Complies

Melatonin (CAS 73-31-4)

Melatonin (CAS 73-31-4) References

SAMPLE Certificate of Analysis (COA)

How to request a Certificate of Analysis (COA) when it is not available online?

Melatonin, 1 g

Melatonin, 5 g

Melatonin, 25 g

Melatonin, 100 g

Melatonin, 250 g

Melatonin, 1 kg

请问melatonin的纯度是HPLC级别吗，想购买作标准品用

Hello, I would like to know if Melatonin is soluble in a mix of CBD distillate (50%) and pure MCT-C8 oil.

Hello, I want to ask for the best way to dissolve melatonin for application in plant in vitro culture, is it autoclavable with other media components ? If no, how do I prepare it and for how long could it be stored in its dissolved condition. Thank you

Es grado Alimentario?

in which solvent we can make a solution of melatonin for its application to crop plants?