Molecular structure of Melagatran, CAS Number: 159776-70-2
Melagatran (CAS 159776-70-2)
See product citations (1)
Alternate Names:
H-319/68
Application:
Melagatran is A thrombin mutant anticoagulant antagonist.
CAS Number:
159776-70-2
Purity:
≥95%
Molecular Weight:
429.51
Molecular Formula:
C22H31N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Melagatran is an antithrombic agent which functions by preventing tissue factor expression in human platelet-monocyte heterotypic complexes. Studies indicate that Melagatran causes fibrinolytic activity fairly comparable to that observed in platelet-poor models which consist of tissue factor-induced clots. In addition, these studies determined that the fibrinolysis ability of Melagatran is not affected by the presence of platelets. Melagatran effects platelet aggregation in a dose dependent manner, with low concentration having the greater effectiveness. Also it has been suggested that Melagatran can differentially inhibit γ-thrombin/PAR-4 receptors over α-thrombin/PAR-1 receptors.
Melagatran (CAS 159776-70-2) References
- Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. | Eriksson, M., et al. 2000. Expert Opin Investig Drugs. 9: 1129-37. PMID: 11060733
- The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review. | Gustafsson, D. and Elg, M. 2003. Thromb Res. 109 Suppl 1: S9-15. PMID: 12818629
- Low potential for interactions between melagatran/ximelagatran and other drugs, food, or alcohol. | Wolzt, M., et al. 2005. Semin Vasc Med. 5: 254-8. PMID: 16123912
- Melagatran for thromboprophylaxis after mechanical valve implantation: results in a heterotopic porcine model. | Thompson, JL., et al. 2007. J Thorac Cardiovasc Surg. 134: 359-65. PMID: 17662773
- The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile. | Testa, L., et al. 2007. Expert Opin Drug Saf. 6: 397-406. PMID: 17688383
- Effect of low and high dose melagatran and other antithrombotic drugs on platelet aggregation. | Soslau, G., et al. 2008. J Thromb Thrombolysis. 25: 198-203. PMID: 17710375
- Profibrinolytic activity of the direct thrombin inhibitor melagatran and unfractionated heparin in platelet-poor and platelet-rich clots. | Semeraro, F., et al. 2007. Thromb Haemost. 98: 1208-14. PMID: 18064315
- Melagatran prevents tissue factor expression in human platelet-monocyte heterotypic complexes. | Belliard, A., et al. 2008. Cell Mol Biol (Noisy-le-grand). 54 Suppl: OL1077-82. PMID: 19149969
- Melagatran, a direct thrombin inhibitor, but not edoxaban, a direct factor Xa inhibitor, nor heparin aggravates tissue factor-induced hypercoagulation in rats. | Furugohri, T., et al. 2012. Eur J Pharmacol. 686: 74-80. PMID: 22546231
- Prolongation of clot lysis time by a direct thrombin inhibitor melagatran mediated by paradoxical enhancement of thrombin generation: comparison with a direct factor Xa inhibitor edoxaban. | Morishima, Y., et al. 2021. Blood Coagul Fibrinolysis. 32: 209-215. PMID: 33560005
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Melagatran, 1 mg | sc-207846 | 1 mg | $390.00 | |||
Melagatran, 5 mg | sc-207846A | 5 mg | $1600.00 | |||
Melagatran, 10 mg | sc-207846B | 10 mg | $2800.00 | |||
Melagatran, 25 mg | sc-207846C | 25 mg | $5600.00 | |||
Melagatran, 100 mg | sc-207846D | 100 mg | $13000.00 |