MEKK 15 Antibody (D-6): sc-514606

MEKK 15 Antibody (D-6) is a mouse monoclonal IgM kappa antibody that detects MEKK 15 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MEKK 15 antibody (D-6) is available as the non-conjugated form. MEKK 15, also known as MAP3K15, is a critical component of the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a vital role in regulating various cellular processes, including cell proliferation, differentiation, and survival. This 1,313 amino acid protein features a protein kinase domain that enables functioning as a serine/threonine kinase, catalyzing the phosphorylation of target proteins in response to extracellular signals. The phosphorylation of proteins is essential for modulating activity and interactions, thereby influencing key cellular functions. MEKK 15 is particularly important in stress responses and developmental signaling, as MAP3K15 can activate downstream kinases that ultimately lead to cellular responses to growth factors and stress stimuli. The gene encoding MEKK 15 is located on human chromosome X, which is significant as this chromosome is associated with various genetic disorders and plays a crucial role in sex determination and development.

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MEKK 15 Antibody (D-6) References:

1. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members.  |  Hanks, SK. and Quinn, AM. 1991. Methods Enzymol. 200: 38-62. PMID: 1956325
2. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.  |  Hanks, SK., et al. 1988. Science. 241: 42-52. PMID: 3291115
3. Sequence patterns in protein kinases.  |  Bairoch, A. and Claverie, JM. 1988. Nature. 331: 22. PMID: 3340146
4. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.  |  Hanes, J., et al. 1994. J Mol Biol. 244: 665-72. PMID: 7990150
5. A new region of conservation is defined between human and mouse X chromosomes.  |  Dinulos, MB., et al. 1996. Genomics. 35: 244-7. PMID: 8661129

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEKK 15 Antibody (D-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MEKK 15 Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEKK 15 Antibody (D-6) Specifications

Alternate Product Name: MEKK 15

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 979-996

Epitope Target: MEKK 15

Epitope Species: human

Product Reactivity/Detection: MEKK 15

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MEKK 15 Antibody (D-6): P: Blocking Peptide