Molecular structure of MEK Inhibitor II, CAS Number: 623163-52-0
MEK Inhibitor II (CAS 623163-52-0)
See product citations (1)
Alternate Names:
2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone
Application:
MEK Inhibitor II is a selectively potent MEK inhibitor, showing little effect on PKC and PKA
CAS Number:
623163-52-0
Molecular Weight:
289.70
Molecular Formula:
C14H8NO4Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
MEK Inhibitor II is a selectively potent MEK inhibitor, showing little effect on PKC and PKA. Inhibits Raf1 and ERK1, but only at much higher concentrations. MEK Inhibitor II is cell-permeable. MEK Inhibitor II, also referred to as MEKi-2, is an easily absorbed small molecule that hinders the activity of MEK, an enzyme in the MAPK/ERK pathway. It demonstrates potent inhibition against both MEK1 and MEK2, exhibiting IC50 values of 0.3 nM and 0.4 nM, respectively. Moreover, MEK Inhibitor II has been utilized to examine the effects of MEK inhibition on tumor growth in animal models.
MEK Inhibitor II (CAS 623163-52-0) References
- Synthesis and MEK1 inhibitory activities of imido-substituted 2-chloro-1,4-naphthoquinones. | Bakare, O., et al. 2003. Bioorg Med Chem. 11: 3165-70. PMID: 12818679
- Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas. | Faber, AC., et al. 2006. Biochem Pharmacol. 72: 1246-56. PMID: 16979140
- Cytotoxicity of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone in androgen-dependent and -independent prostate cancer cell lines. | Copeland, RL., et al. 2007. Anticancer Res. 27: 1537-46. PMID: 17595773
- Cytotoxic effects of N-(3-chloro-1,4-dioxo 1,4-dihydro-naphthalen-2-yl)-benzamide on androgen-dependent and -independent prostate cancer cell lines. | Kanaan, YM., et al. 2010. Anticancer Res. 30: 519-27. PMID: 20332464
- Synthesis and cytotoxic activities of some 2-arylnaphtho[2,3-d]oxazole-4,9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines. | Brandy, Y., et al. 2012. Invest New Drugs. 30: 1709-14. PMID: 21243402
- Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells. | Ikari, A., et al. 2012. Biochim Biophys Acta. 1823: 1110-8. PMID: 22546605
- Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives. | Brandy, Y., et al. 2013. Molecules. 18: 1973-84. PMID: 23381023
- Forecasting cell death dose-response from early signal transduction responses in vitro. | Vrana, JA., et al. 2014. Toxicol Sci. 140: 338-51. PMID: 24824809
Inhibitor of:
Enzyme, and MEK-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK Inhibitor II, 5 mg | sc-205745 | 5 mg | $122.00 | |||
MEK Inhibitor II, 10 mg | sc-205745A | 10 mg | $245.00 |