MEK-3 Antibody (B-5): sc-271779

MEK-3 Antibody (B-5) is a mouse monoclonal IgG3 kappa light chain antibody that detects MEK-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-MEK-3 antibody (B-5) is available as the non-conjugated form. MEK-3, also known as MKK-3, plays a crucial role in cellular signaling by specifically activating the p38 MAP kinase pathway, which is essential for various cellular responses, including inflammation, stress responses, and apoptosis. MEK-3 activation of p38 MAP kinase is particularly important in mediating cellular response to environmental stressors, such as cytokines and UV radiation, thereby influencing cell survival and differentiation. Understanding MEK-3 function and its role in the p38 MAP kinase pathway is vital for elucidating mechanisms underlying various diseases, including cancer and inflammatory disorders. Anti-MEK-3 antibody (B-5) serves as an invaluable tool for researchers investigating the complexities of cellular signaling and its implications in health and disease.

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MEK-3 Antibody (B-5) References:

1. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product.  |  Crews, CM., et al. 1992. Science. 258: 478-80. PMID: 1411546
2. Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications.  |  Baldari, S., et al. 2015. Cell Death Dis. 6: e1621. PMID: 25633290
3. miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells.  |  Peng, R., et al. 2020. Gene. 724: 144146. PMID: 31634561
4. Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharyngeal Carcinoma.  |  Chiang, C., et al. 2020. Theranostics. 10: 7906-7920. PMID: 32685028
5. Components of a new human protein kinase signal transduction pathway.  |  Zhou, G., et al. 1995. J Biol Chem. 270: 12665-9. PMID: 7759517
6. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.  |  Dérijard, B., et al. 1995. Science. 267: 682-5. PMID: 7839144
7. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.  |  Wu, J., et al. 1993. Mol Cell Biol. 13: 4539-48. PMID: 8393135
8. Characterization of the structure and function of a novel MAP kinase kinase (MKK6).  |  Han, J., et al. 1996. J Biol Chem. 271: 2886-91. PMID: 8621675
9. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
10. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.  |  Tournier, C., et al. 1997. Proc Natl Acad Sci U S A. 94: 7337-42. PMID: 9207092
11. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.  |  Holland, PM., et al. 1997. J Biol Chem. 272: 24994-8. PMID: 9312105
12. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.  |  Wu, Z., et al. 1997. Mol Cell Biol. 17: 7407-16. PMID: 9372971

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEK-3 Antibody (B-5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-MEK-3 Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEK-3 Antibody (B-5) Specifications

Alternate Product Name: MEK-3

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 32-61

Epitope Target: MEK-3

Epitope Species: human

Product Reactivity/Detection: MEK-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for MEK-3 Antibody (B-5): P: Blocking Peptide

The preferred p-MEK-3/6 antibody is p-MEK-3/6 Antibody (B-9): sc-8407.