MEK-3 Antibody (B-2): sc-376627
- MEK-3 Antibody (B-2) is a mouse monoclonal IgM κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 291-320 at the C-terminus of MEK-3 of human origin
- recommended for detection of MEK-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MEK-3 Antibody (B-2). This work is in progress.
MEK-3 Antibody (B-2) is a mouse monoclonal IgM antibody that detects MEK-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MEK-3, also known as MKK-3, plays a crucial role in the activation of the p38 MAP kinase pathway, which is essential for cellular responses to stress, inflammation, and differentiation. By phosphorylating specific threonine and tyrosine residues on p38 MAP kinase, MEK-3 facilitates the transmission of signals that regulate various biological processes, including cell growth, apoptosis, and immune responses. The importance of MEK-3 in these pathways highlights MEK-3′s potential as a therapeutic target in diseases characterized by dysregulated MAP kinase signaling, such as cancer and inflammatory disorders. Anti-MEK-3 antibody (B-2) provides a reliable tool for researchers aiming to explore the intricate mechanisms of MAP kinase signaling and its implications in health and disease.
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MEK-3 Antibody (B-2) References:
- Mitogen-activated protein kinase cascade and transcription factors: the opposite role of MKK3/6-p38K and MKK1-MAPK. | Terada, Y., et al. 1999. Nephrol Dial Transplant. 14 Suppl 1: 45-7. PMID: 10048449
- Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. | Prickett, TD. and Brautigan, DL. 2007. Mol Cell Biol. 27: 4217-27. PMID: 17438131
- MKK3 deletion improves mitochondrial quality. | Srivastava, A., et al. 2015. Free Radic Biol Med. 87: 373-84. PMID: 26119780
- MKK3 modulates JNK-dependent cell migration and invasion. | Sun, Y., et al. 2019. Cell Death Dis. 10: 149. PMID: 30770795
- Rab GTPase 21 mediates caerulin-induced TRAF3-MKK3-p38 activation and acute pancreatitis response. | Wang, N., et al. 2019. Biochem Biophys Res Commun. 518: 50-58. PMID: 31402118
- MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer. | Stramucci, L., et al. 2019. Cell Death Dis. 10: 842. PMID: 31695024
- MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis. | Lin, CL., et al. 2021. Cell Death Dis. 12: 451. PMID: 33958583
- Targeting PRSS23 with tipranavir induces gastric cancer stem cell apoptosis and inhibits growth of gastric cancer via the MKK3/p38 MAPK-IL24 pathway. | Xiong, JX., et al. 2024. Acta Pharmacol Sin. 45: 405-421. PMID: 37814123
- Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis. | Valuparampil Varghese, M., et al. 2024. Am J Physiol Lung Cell Mol Physiol. 327: L574-L586. PMID: 39197168
- Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. | Rampoldi, L., et al. 1997. Cytogenet Cell Genet. 78: 301-3. PMID: 9465908
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK-3 Antibody (B-2) | sc-376627 | 200 µg/ml | $322.00 | |||
MEK-3 (B-2) Neutralizing Peptide | sc-376627 P | 100 µg/0.5 ml | $69.00 |