MEK-3 Antibody (5F7): sc-81474
- MEK-3 Antibody (5F7) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against N-terminus of MEK-3 of human origin
- recommended for detection of MEK-3 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MEK-3 Antibody (5F7). This work is in progress.
MEK-3 Antibody (5F7) is a mouse monoclonal IgG1 antibody that detects MEK-3 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). MEK-3, also known as MKK-3, plays a crucial role in the activation of the p38 MAP kinase pathway, which is essential for cellular responses to stress and inflammation. By phosphorylating specific threonine and tyrosine residues on p38 MAP kinase, MEK-3 facilitates the transmission of signals that regulate various biological processes, including cell differentiation, apoptosis, and the immune response. The importance of MEK-3 in these pathways highlights MEK-3′s potential as a therapeutic target in diseases characterized by dysregulated MAP kinase signaling, such as cancer and inflammatory disorders. Anti-MEK-3 antibody (5F7) provides reliable detection and characterization of this vital protein, enabling researchers to explore MEK-3 functions and interactions in greater detail.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MEK-3 Antibody (5F7) References:
- MKK3 mediates inflammatory response through modulation of mitochondrial function. | Srivastava, A., et al. 2015. Free Radic Biol Med. 83: 139-48. PMID: 25697779
- Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts. | Du, J., et al. 2016. Am J Physiol Cell Physiol. 310: C270-83. PMID: 26739490
- Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia. | Meng, H., et al. 2016. J Dent Res. 95: 1169-75. PMID: 27418173
- Convergence of Multiple MAP3Ks on MKK3 Identifies a Set of Novel Stress MAPK Modules. | Colcombet, J., et al. 2016. Front Plant Sci. 7: 1941. PMID: 28066492
- Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer. | Stramucci, L., et al. 2018. Cancers (Basel). 10: PMID: 29751559
- Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation. | Ayala-Marin, YM., et al. 2021. Int J Mol Sci. 22: PMID: 34830095
- MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation. | Romero-Becerra, R., et al. 2022. Elife. 11: PMID: 35971771
- Activated MKK3/MYC crosstalk impairs dabrafenib response in BRAFV600E colorectal cancer leading to resistance. | Pranteda, A., et al. 2023. Biomed Pharmacother. 167: 115480. PMID: 37713993
- MKK3 K329 Mutation Attenuates Diabetes-Associated Cognitive Dysfunction by Blocking the MKK3-RAGE Interaction and Inhibiting Neuroinflammation. | Ying, C., et al. 2024. Aging Dis. 16: 598-618. PMID: 38421831
- Repurposed AT9283 triggers anti-tumoral effects by targeting MKK3 oncogenic functions in Colorectal Cancer. | Piastra, V., et al. 2024. J Exp Clin Cancer Res. 43: 234. PMID: 39164711
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK-3 Antibody (5F7) | sc-81474 | 50 µg/0.5 ml | $322.00 |