MEHP (CAS 4376-20-9)
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MEHP functions as a plasticizer, used in experimental applications to modify the properties of polymers. It acts by interacting with the polymer chains, increasing their flexibility and making them more pliable. This allows for the creation of materials with improved durability and resistance to wear and tear. At the molecular level, MEHP disrupts the packing of polymer chains, reducing the intermolecular forces and enabling the material to become more flexible. MEHP′s mechanism of action involves binding to the polymer matrix, altering its physical properties without undergoing significant chemical changes itself. In experimental applications, MEHP plays a role in modifying the mechanical and thermal properties of polymers, contributing to the development of materials with enhanced performance characteristics.
MEHP (CAS 4376-20-9) References
- MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. | Yang, G., et al. 2012. Food Chem Toxicol. 50: 2424-31. PMID: 22542555
- Melatonin protects oocytes from MEHP exposure-induced meiosis defects in porcine. | Zhang, Y., et al. 2018. Biol Reprod. 98: 286-298. PMID: 29373650
- MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis. | Voss, JJLP., et al. 2018. Reproduction. 156: 35-46. PMID: 29743262
- MEHP promotes the proliferation of oral cancer cells via down regulation of miR-27b-5p and miR-372-5p. | Wang, M., et al. 2019. Toxicol In Vitro. 58: 35-41. PMID: 30858031
- Mono(2-ethylhexyl) phthalate (MEHP) induces transcriptomic alterations in oocytes and their derived blastocysts. | Kalo, D., et al. 2019. Toxicology. 421: 59-73. PMID: 31059758
- MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells. | Chen, YH., et al. 2020. Biosci Rep. 40: PMID: 32255176
- MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement. | Tête, A., et al. 2020. Food Chem Toxicol. 146: 111798. PMID: 33022287
- Mono-2-ethylhexyl phthalate drives progression of PINK1-parkin-mediated mitophagy via increasing mitochondrial ROS to exacerbate cytotoxicity. | Xu, J., et al. 2021. Redox Biol. 38: 101776. PMID: 33161305
- Role of estrogen receptor alpha in MEHP-induced proliferation and invasion of SH-SY5Y cells. | Guo, S., et al. 2021. Toxicology. 453: 152734. PMID: 33631300
- Low-dose mono(2-ethylhexyl) phthalate promotes ovarian cancer development through PPARα-dependent PI3K/Akt/NF-κB pathway. | Leng, J., et al. 2021. Sci Total Environ. 790: 147990. PMID: 34380243
- Mechanisms of MEHP Inhibitory Action and Analysis of Potential Replacement Plasticizers on Leydig Cell Steroidogenesis. | Enangue Njembele, AN. and Tremblay, JJ. 2021. Int J Mol Sci. 22: PMID: 34768887
- In vitro impact of genistein and mono(2-ethylhexyl) phthalate (MEHP) on the eicosanoid pathway in spermatogonial stem cells. | Tran-Guzman, A., et al. 2022. Reprod Toxicol. 107: 150-165. PMID: 34942354
- MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes. | Zhang, Y., et al. 2022. Chemosphere. 295: 133925. PMID: 35143864
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEHP, 100 mg | sc-396467 | 100 mg | $401.00 |